强直性脊柱炎的中医治疗研究进展

Research Progress on the Treatment of Ankylosing Spondylitis with Traditional Chinese Medicine

摘要: 强直性脊柱炎(ankylosing spondylitis, AS)是一种以中轴关节慢性炎症为主的全身性疾病，病变主要累及骶髂关节，常发生椎间盘纤维化及其附近韧带钙化和骨性强直，其特征性病理变化是肌腱、韧带、骨附着点的病变，影响患者的运动功能和生活质量，有潜在的致残风险。在治疗上，西医治疗主要以非甾体抗炎药、生物制剂和物理治疗为主，而西医治疗存在着药物不良反应及费用高昂或耐药等局限。中医药采用辨证论治及辅助中医外治的方法，在缓解症状、减少复发等方面具有独特的优势。近年来，中医治疗AS取得了显著的进展，该综述系统梳理了中医内治与外治的多种手段治疗AS的研究进展，对于临床医生寻找替代或辅助治疗方案具有一定的参考价值，有助于推广中医药在风湿免疫病领域的应用。

Abstract: Ankylosing spondylitis (AS) is a systemic disease mainly characterized by chronic inflammation of the axial joints, with the sacroiliac joint being the primary site of involvement. It often leads to intervertebral disc fibrosis, calcification of nearby ligaments, and bony ankylosis. The characteristic pathological change is the lesion at the attachment points of tendons, ligaments, and bones, which affects the patient’s motor function and quality of life, and has a potential risk of disability. In terms of treatment, Western medicine mainly uses non-steroidal anti-inflammatory drugs, biological agents, and physical therapy. However, Western medical treatment has limitations such as adverse drug reactions, high costs, or drug resistance. Traditional Chinese medicine (TCM) adopts the methods of syndrome differentiation and treatment and auxiliary external therapy, which have unique advantages in relieving symptoms and reducing recurrence. In recent years, significant progress has been made in the treatment of AS with TCM. This review systematically summarizes the research progress of various TCM internal and external treatment methods for AS, which has certain reference value for clinicians seeking alternative or adjunctive treatment options and is conducive to promoting the application of TCM in the field of rheumatology and immunology.