慢性失眠障碍血清脂联素水平改变及其 与睡眠参数的相关性研究
Study on the Changes of Serum Adiponectin Levels in Chronic Insomnia Disorders and Their Correlation with Sleep Parameters
DOI: 10.12677/acm.2026.163988, PDF,   
作者: 邹甜甜：安徽医科大学第四附属医院神经内科，安徽 合肥；陈贵海*：安徽医科大学第四附属医院睡眠障碍科，安徽 合肥
关键词: 慢性失眠障碍；PSQI；PSG；脂联素；Chronic Insomnia Disorder； PSQI； PSG； Adiponectin
摘要: 目的：探讨慢性失眠障碍(CID)脂联素浓度改变及其与睡眠参数之间的关系。方法：CID患者57名，健康对照(HC) 57名。匹兹堡睡眠质量指数(PSQI) (n = 57)多导睡眠图(PSG) (n = 17)评估失眠程度。ELISA检测血清脂联素水平。结果：与HC相比，CID组PSQI分数升高，脂联素水平降低(P均<0.001)。偏相关分析(控制性别、年龄、BMI、教育年限、焦虑和抑郁因素)显示CID组血清脂联素与PSQI分数负相关(P < 0.01)，与REM睡眠潜伏期负相关(P < 0.05)。结论：CID患者血清脂联素代谢紊乱，且其与失眠严重程度相关。
Abstract: Objective: To explore the changes in adiponectin concentration in chronic insomnia disorder (CID) and its relationship with sleep parameters. Method: There were 57 CID patients and 57 healthy controls (HC). The Pittsburgh Sleep Quality Index (PSQI) (n = 57) and polysomnography (PSG) (n = 17) are used to assess the degree of insomnia. Serum adiponectin levels were detected by ELISA. Result: Compared with HC, the PSQI score in the CID group increased and the adiponectin level decreased (all P < 0.001). Partial correlation analysis (controlling for gender, age, BMI, years of education, anxiety and depression factors) showed that serum adiponectin in the CID group was negatively correlated with PSQI score (P < 0.01) and negatively correlated with REM sleep latency (P < 0.05). Conclusion: Serum adiponectin metabolism is disordered in CID patients, and it is related to the severity of insomnia.
文章引用：邹甜甜, 陈贵海. 慢性失眠障碍血清脂联素水平改变及其 与睡眠参数的相关性研究[J]. 临床医学进展, 2026, 16(3): 2000-2007. https://doi.org/10.12677/acm.2026.163988

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