炎性因子在缺血性卒中的作用以及SERS的 应用探讨
The Role of Inflammatory Factors in Ischemic Stroke and the Application of SERS
DOI: 10.12677/acm.2026.1631019, PDF,   
作者: 付 雪:暨南大学附属第一医院神经内科,广东 广州;杨万勇*:暨南大学附属第五医院神经内科,广东 河源
关键词: 急性缺血性卒中炎性因子表面增强拉曼光谱Acute Ischemic Stroke Inflammatory Factors Surface-Enhanced Raman Spectroscopy
摘要: 急性缺血性卒中(AIS)是由于脑部血液供应中断导致的缺血性损伤,是全球范围内导致死亡和残疾的主要疾病之一。其病理机制复杂,涉及血管损伤、血栓形成以及随后水肿、氧化应激和直接诱导神经元死亡。因此,炎性因子对急性缺血性卒中的影响,抗炎治疗对急性缺血性卒中患者的神经保护作用受到广泛关注。但目前临床上对血清炎性指标的检测存在诸多限制,无法对急性缺血性卒中患者血清炎性因子进行精准快速的检测,对临床抗炎治疗不能提供技术指导。而表面增强拉曼光谱(SERS)作为一种基于分子振动的光谱技术,因其操作便捷、高灵敏度、高特异性和非破坏性检测的特点,近年来在炎症因子的检测中得到了广泛关注和应用。本文结合国内外研究进展,综合急性缺血性卒中与炎症因子的关系,以及SERS检测技术特点,为急性缺血性卒中精准诊治进行探索。
Abstract: Acute Ischemic Stroke (AIS) is an ischemic injury caused by the interruption of cerebral blood supply and is one of the leading causes of death and disability worldwide. Its pathological mechanism is complex, involving vascular injury, thrombosis and subsequent edema, oxidative stress and direct induction of neuronal death. Therefore, the impact of inflammatory factors on AIS and the neuroprotective effects of anti-inflammatory therapy in AIS patients have garnered widespread attention. However, current clinical detection of serum inflammatory markers faces numerous limitations, making it difficult to achieve rapid and precise measurement of inflammatory factors in AIS patients, thereby failing to provide technical guidance for clinical anti-inflammatory treatment. Surface-enhanced Raman spectroscopy (SERS), a molecular vibration-based spectroscopic technique, has gained increasing attention and application in the detection of inflammatory factors due to its operational convenience, high sensitivity, high specificity, and non-destructive detection capabilities. This article integrates domestic and international research advancements, synthesizes the relationship between AIS and inflammatory factors, and explores the characteristics of SERS detection technology to contribute to the precision diagnosis and treatment of AIS.
文章引用:付雪, 杨万勇. 炎性因子在缺血性卒中的作用以及SERS的 应用探讨[J]. 临床医学进展, 2026, 16(3): 2250-2257. https://doi.org/10.12677/acm.2026.1631019

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