恶性梗阻性黄疸的综合治疗策略： 熊去氧胆酸、丁二磺酸腺苷蛋氨酸 及PTCD支架置入术的研究进展

Comprehensive Treatment Strategies for Malignant Obstructive Jaundice: Advances in Ursodeoxycholic Acid, Ademetionine 1,4-Butanedisulfonate, and PTCD with Stent Placement

摘要: 恶性梗阻性黄疸作为肝胆系统恶性肿瘤严重并发症，发病率伴随全球癌症负担加重而升高，患者肝功能生活质量遭受严重损害，这成为高病死率关键因素，当前临床中传统单一疗法效果有限，黄疸难以快速解除，生存期生活质量难以兼顾，探索高效综合治疗策略已是临床迫切需求，本文通过文献系统回顾临床数据整合，综述综合治疗最新进展，聚焦药物介入疗法协同应用，分析熊去氧胆酸丁二磺酸腺苷蛋氨酸药理作用，分析经皮肝穿刺胆道引流支架置入术应用要点，构建序贯式综合治疗框架评估疗效，结果表明药物联合经皮肝穿刺胆道引流支架置入术综合模式，姑息治疗效果获得显著提升，患者预后得到改善，这为优化治疗指南前瞻性研究提供理论依据方向指引。

Abstract: Malignant obstructive jaundice (MOJ), a severe complication of malignant tumors in the hepatobiliary system, has an increasing incidence with the growing global cancer burden. This complication can lead to severe impairment of liver function and a significant decline in quality of life in patients, which is a key factor contributing to the high mortality rate of such patients. In current clinical practice, traditional single treatment regimens have limited efficacy, making it difficult to quickly relieve jaundice symptoms and effectively balance patients’ survival time and quality of life. Therefore, exploring efficient and feasible comprehensive treatment strategies has become an urgent clinical need. Through systematic review of literature and integration of clinical data, this article summarizes the latest research advances in the comprehensive treatment of malignant obstructive jaundice, focusing on the synergistic application of drugs and interventional therapy, deeply analyzing the pharmacological effects of ursodeoxycholic acid and ademetionine 1,4-butanedisulfonate, as well as the clinical application points of percutaneous transhepatic biliary drainage (PTBD) combined with stent implantation. A sequential comprehensive treatment framework was constructed and its clinical efficacy was evaluated. The results show that the comprehensive treatment mode of drugs combined with PTBD and stent implantation can significantly improve the palliative treatment effect and effectively enhance the prognosis of patients with malignant obstructive jaundice, providing a solid theoretical basis and clear direction for the optimization of clinical treatment guidelines and subsequent prospective studies.