基于SWI影像组学的脑卒中复发预测研究进展
Advanced on a Radiomics-Based Model for SWI Feature Extraction and Recurrence Risk Prediction in Stroke
摘要: 脑卒中是一种对人类生命健康危害极大的疾病,且由于其高复发特性使患者不良结局加重、生存质量下降,是全球致死致残的关键因素。当前临床实践广泛应用的CHADS2、ABCD2量表等复发风险预测体系大多依靠常规危险指标,而未能很好把握个体独特病理特征,预报效果存在很大局限性。而医学影像海量量化特征的提取给疾病结局预测开创新路,磁敏感加权成像(SWI)探测能力强,可精准识别脑内微小出血灶、静脉血氧水平波动、铁质异常沉积等病理特征,在微血管病变显影方面的能力是常规影像学技术难以相比的。影像组学技术的发展为脑卒中复发风险的个体化精准预测提供了新的可能。
Abstract: Stroke is a critical disease that poses a significant threat to human life and health, and its high recurrence rate exacerbates poor outcomes and reduces quality of life for patients, making it a key factor in global mortality and disability. Current clinical practices widely use recurrence risk prediction systems such as the CHADS2 and ABCD2 scales, which primarily rely on conventional risk indicators and fail to adequately capture individual unique pathological features, resulting in significant limitations in predictive accuracy. The extraction of massive quantitative features from medical imaging has opened new avenues for predicting disease outcomes. Susceptibility-weighted imaging (SWI) exhibits strong detection capabilities, enabling precise identification of pathological features such as microbleeding foci in the brain, fluctuations in venous oxygen levels, and abnormal iron deposition. Its ability to visualize microvascular lesions surpasses that of conventional imaging techniques. The development of radiomics technology provides new possibilities for the personalized and precise prediction of stroke recurrence risk.
文章引用:田程, 李子妍, 李昱辉, 汪思睿, 马瑞健, 刘堇. 基于SWI影像组学的脑卒中复发预测研究进展[J]. 临床医学进展, 2026, 16(3): 2574-2580. https://doi.org/10.12677/acm.2026.1631057

参考文献

[1] Zwanenburg, A., Vallières, M., Abdalah, M.A., Aerts, H.J.W.L., Andrearczyk, V., Apte, A., et al. (2020) The Image Biomarker Standardization Initiative: Standardized Quantitative Radiomics for High-Throughput Image-Based Phenotyping. Radiology, 295, 328-338. [Google Scholar] [CrossRef] [PubMed]
[2] 中华医学会神经病学分会, 中华医学会神经病学分会脑血管病学组. 中国急性缺血性脑卒中诊疗指南(2023版) [J]. 中华神经科杂志, 2023, 56(1): 29-53.
[3] ElSadek, A., Gaber, A., Afifi, H., Farag, S. and Salaheldien, N. (2019) Microemboli versus Hypoperfusion as an Etiology of Acute Ischemic Stroke in Egyptian Patients with Watershed Zone Infarction. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 55, Article No. 2. [Google Scholar] [CrossRef] [PubMed]
[4] Hobeanu, C., Lavallée, P.C., Charles, H., Labreuche, J., Albers, G.W., Caplan, L.R., et al. (2022) Risk of Subsequent Disabling or Fatal Stroke in Patients with Transient Ischaemic Attack or Minor Ischaemic Stroke: An International, Prospective Cohort Study. The Lancet Neurology, 21, 889-898. [Google Scholar] [CrossRef] [PubMed]
[5] Cucchiara, B., Elm, J., Easton, J.D., Coutts, S.B., Willey, J.Z., Biros, M.H., et al. (2020) Disability after Minor Stroke and Transient Ischemic Attack in the POINT Trial. Stroke, 51, 792-799. [Google Scholar] [CrossRef] [PubMed]
[6] Xing, Y., Jin, Y. and Liu, Y. (2024) Construction and Comparison of Short-Term Prognosis Prediction Model Based on Machine Learning in Acute Ischemic Stroke. Heliyon, 10, e24232. [Google Scholar] [CrossRef] [PubMed]
[7] Fabiani, I., Palombo, C., Caramella, D., Nilsson, J. and De Caterina, R. (2020) Imaging of the Vulnerable Carotid Plaque. Neurology, 94, 922-932. [Google Scholar] [CrossRef] [PubMed]
[8] Zaccagna, F., Ganeshan, B., Arca, M., Rengo, M., Napoli, A., Rundo, L., et al. (2021) CT Texture-Based Radiomics Analysis of Carotid Arteries Identifies Vulnerable Patients: A Preliminary Outcome Study. Neuroradiology, 63, 1043-1052. [Google Scholar] [CrossRef] [PubMed]
[9] Ding, G., Xu, J., He, J. and Nie, Z. (2022) Clinical Scoring Model Based on Age, NIHSS, and Stroke-History Predicts Outcome 3 Months after Acute Ischemic Stroke. Frontiers in Neurology, 13, Article ID: 935150. [Google Scholar] [CrossRef] [PubMed]
[10] 王玥, 侯晓雯, 陈会生, 等. 基于颅内斑块影像组学联合传统标志物预测缺血性脑卒中复发风险[J]. 磁共振成像, 2023, 14(8): 1-9.
[11] Lambin, P., Rios-Velazquez, E., Leijenaar, R., Carvalho, S., van Stiphout, R.G.P.M., Granton, P., et al. (2012) Radiomics: Extracting More Information from Medical Images Using Advanced Feature Analysis. European Journal of Cancer, 48, 441-446. [Google Scholar] [CrossRef] [PubMed]
[12] Liu, J., Wu, Y., Jia, W., Han, M., Chen, Y., Li, J., et al. (2023) Prediction of Recurrence of Ischemic Stroke within 1 Year of Discharge Based on Machine Learning MRI Radiomics. Frontiers in Neuroscience, 17, Article ID: 1110579. [Google Scholar] [CrossRef] [PubMed]
[13] 曹婷婷, 潘兆烨, 赵雨薇, 等. 颅内动脉责任斑块的3D-HRVWI组学特征联合斑块内出血对缺血性卒中患者复发的预测效能研究[J]. 磁共振成像, 2025, 16(3): 24-30, 50.
[14] Xie, K. and Sun, H. (2017) Recent Advances in Feature Extraction for Radiomics. Chinese Journal of Medical Imaging Technology, 33, 1792-1796.
[15] Fukuda, K., Iihara, K., Maruyama, D., Yamada, N. and Ishibashi-Ueda, H. (2014) Relationship between Carotid Artery Remodeling and Plaque Vulnerability with T1-Weighted Magnetic Resonance Imaging. Journal of Stroke and Cerebrovascular Diseases, 23, 1462-1470. [Google Scholar] [CrossRef] [PubMed]
[16] Ramos, L.A., Os, H.V., Hilbert, A., Olabarriaga, S.D., Lugt, A.V.d., Roos, Y.B.W.E.M., et al. (2022) Combination of Radiological and Clinical Baseline Data for Outcome Prediction of Patients with an Acute Ischemic Stroke. Frontiers in Neurology, 13, Article ID: 809343. [Google Scholar] [CrossRef] [PubMed]
[17] Xia, Y., Li, L., Liu, P., Zhai, T. and Shi, Y. (2025) Machine Learning Prediction Model for Functional Prognosis of Acute Ischemic Stroke Based on MRI Radiomics of White Matter Hyperintensities. BMC Medical Imaging, 25, Article No. 91. [Google Scholar] [CrossRef] [PubMed]
[18] Breiman, L. (2001) Random Forests. Machine Learning, 45, 5-32. [Google Scholar] [CrossRef
[19] 刘建茂, 吴一帆, 贾伟杰, 等. 基于机器学习MRI影像组学预测缺血性脑卒中出院1年内复发情况[J]. 神经科学前沿, 2023, 17: 1110579.
[20] Quan, G., Ban, R., Ren, J., Liu, Y., Wang, W., Dai, S., et al. (2021) FLAIR and ADC Image-Based Radiomics Features as Predictive Biomarkers of Unfavorable Outcome in Patients with Acute Ischemic Stroke. Frontiers in Neuroscience, 15, Article ID: 730879. [Google Scholar] [CrossRef] [PubMed]
[21] 中华医学会神经病学分会脑血管病学组. 中国缺血性脑卒中二级预防指南(2021版) [J]. 中华神经科杂志, 2021, 54(12): 1101-1118.
[22] van Timmeren, J.E., Cester, D., Tanadini-Lang, S., Alkadhi, H. and Baessler, B. (2020) Radiomics in Medical Imaging—“How-To” Guide and Critical Reflection. Insights into Imaging, 11, Article No. 91. [Google Scholar] [CrossRef] [PubMed]
[23] Nael, K., Khan, R., Choudhary, G., Meshksar, A., Villablanca, P., Tay, J., et al. (2014) Six-Minute Magnetic Resonance Imaging Protocol for Evaluation of Acute Ischemic Stroke. Stroke, 45, 1985-1991. [Google Scholar] [CrossRef] [PubMed]
[24] Eisenmenger, L.B., Aldred, B.W., Kim, S.-E., Stoddard, G.J., de Havenon, A., Treiman, G.S., et al. (2016) Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA. American Journal of Neuroradiology, 37, 1496-1503. [Google Scholar] [CrossRef] [PubMed]
[25] Li, S., Hou, Z., Liu, J., et al. (2018) A Comprehensive Review of Radiomics Analysis and Modeling Tools. Chinese Journal of Medical Physics, 35, 1043-1049.
[26] Brunner, G., Virani, S.S., Sun, W., Liu, L., Dodge, R.C., Nambi, V., et al. (2020) Associations between Carotid Artery Plaque Burden, Plaque Characteristics, and Cardiovascular Events. JAMA Cardiology, 6, 79-86. [Google Scholar] [CrossRef] [PubMed]
[27] Ke, G., Meng, Q., Finley, T., et al. (2017) LightGBM: A Highly Efficient Gradient Boosting Decision Tree. Proceedings of the 31st Annual Conference on Neural Information Processing Systems, Long Beach, 4-9 December 2017, 3146-3154.
[28] Huang, S., Cai, N., Pacheco, P.P., et al. (2018) Applications of Support Vector Machine (SVM) Learning in Cancer Genomics. Cancer Genomics Proteomics, 15, 41-51.
[29] Hosmer, D.W., Lemeshow, S. and Sturdivant, R.X. (2013) Applied Logistic Regression. Wiley. [Google Scholar] [CrossRef
[30] 中华医学会神经病学分会脑血管病学组. 中国缺血性脑血管病血管内介入治疗指南(2023版) [J]. 中华神经科杂志, 2023, 56(5): 429-450.
[31] Vickers, A.J. and Elkin, E.B. (2006) Decision Curve Analysis: A Novel Method for Evaluating Prediction Models. Medical Decision Making, 26, 565-574. [Google Scholar] [CrossRef] [PubMed]
[32] Potter, T.B.H., Tannous, J. and Vahidy, F.S. (2022) A Contemporary Review of Epidemiology, Risk Factors, Etiology, and Outcomes of Premature Stroke. Current Atherosclerosis Reports, 24, 939-948. [Google Scholar] [CrossRef] [PubMed]