TyG及其衍生指数在保留比值受损肺功能诊疗方面的研究进展
Research Progress on TyG Index and Its Derived Indices in the Diagnosis and Treatment of Preserved Ratio Impaired Spirometry
摘要: 保留比值受损肺功能(PRISm)是一种具有独特肺功能表现的功能障碍表型,与心血管代谢紊乱、全身性炎症反应及不良预后风险密切相关。当前PRISm的早期识别与综合管理面临挑战,亟需能够反映其潜在病理生理机制的生物标志物以指导临床实践。反映胰岛素抵抗与代谢紊乱状态的甘油三酯–葡萄糖指数(TyG)及其衍生指标(如TyG-BMI、TyG-WC等),因其与全身低度炎症、氧化应激及多器官功能损害相关,在慢性呼吸系统疾病中的作用日益受到关注。作为综合代谢炎症标志物,这些指标可能为PRISm的病理分型、风险评估及预后预测提供新视角。本文系统阐述PRISm的临床特征与病理基础,综述现有生物标志物研究进展,重点探讨TyG及其衍生指标在慢性呼吸系统疾病特别是PRISm人群中的研究证据,以期为PRISm的早期干预与个体化防治提供理论依据与策略参考。
Abstract: Preserved ratio impaired spirometry (PRISm) is a distinct functional impairment phenotype identified through clinical pulmonary function assessment, characterized by its close associations with cardiovascular metabolic disorders, systemic inflammatory responses, and increased risk of adverse outcomes. Currently, the early identification and comprehensive management of PRISm face significant challenges, highlighting an urgent need for biomarkers that reflect its underlying pathophysiological mechanisms to guide clinical practice. In recent years, the triglyceride-glucose (TyG) index and its derived metrics (such as TyG-BMI and TyG-WC), which reflect insulin resistance and metabolic dysregulation, have garnered increasing attention in the context of chronic respiratory diseases due to their links with systemic low-grade inflammation, oxidative stress, and multi-organ functional impairment. As integrated metabolic-inflammatory markers, these indices offer potential new perspectives for the pathological subtyping, risk assessment, and prognosis prediction of PRISm. This article systematically outlines the clinical characteristics and pathological basis of PRISm, reviews advances in existing biomarker research, and focuses on the evidence regarding TyG and its derived indicators in chronic respiratory diseases, particularly in PRISm populations. The aim is to provide theoretical foundations and strategic insights for the early intervention and personalized management of PRISm.
文章引用:涂倩, 李敏超. TyG及其衍生指数在保留比值受损肺功能诊疗方面的研究进展[J]. 临床医学进展, 2026, 16(3): 2764-2774. https://doi.org/10.12677/acm.2026.1631077

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