肺癌炎癌转化的中医药防治策略及其分子机制研究

Study on TCM Prevention and Treatment Strategies and Their Molecular Mechanisms for Inflammation-Carcinoma Transformation in Lung Cancer

摘要: 慢性肺部炎症向肺癌的转化(“炎癌转化”)与微环境重塑、基因突变及免疫逃逸密切相关。本文系统分析了中医药通过“扶正祛邪”策略干预炎癌转化的理论依据与分子机制。中药复方通过多靶点调控NF-κB、STAT3、NLRP3等信号通路，逆转肿瘤相关巨噬细胞(TAMs)极化，阻断上皮–间质转化(EMT)，并调节肠道菌群。实验数据显示，双参颗粒使肺转移灶减少，苦参碱提升G2/M期阻滞率，黄芪甲苷IV降低M2型巨噬细胞浸润。结合国家癌症中心数据及“治未病”理念，为肺癌一级与二级预防提供新路径。

Abstract: The transformation of chronic pulmonary inflammation to lung cancer, known as “inflammation-cancer transformation”, is closely associated with microenvironmental remodeling, gene mutation and immune escape. In this paper, we systematically analyzed the theoretical basis and molecular mechanisms of traditional Chinese medicine (TCM) intervening in inflammation-cancer transformation based on the strategy of strengthening vital qi to eliminate pathogenic factors. TCM compound prescriptions exert multi-target regulatory effects on signaling pathways including NF-κB, STAT3 and NLRP3, reverse the polarization of tumor-associated macrophages (TAMs), block epithelial-mesenchymal transition (EMT), and modulate the intestinal microbiota. Experimental data indicated that Shuangshen Granules reduced the number of pulmonary metastatic foci, matrine elevated the G2/M phase arrest rate, and astragaloside IV decreased the infiltration of M2-type macrophages. Combined with the data from the National Cancer Center and the TCM concept of preventive treatment of disease, which provides a novel approach for the primary and secondary prevention of lung cancer.