TCA循环重编程:炎症性骨病中骨代谢紊乱的关键机制及治疗靶点
TCA Cycle Reprogramming: A Key Mechanism and Therapeutic Target of Bone Metabolism Disorder in Inflammatory Bone Diseases
DOI: 10.12677/acm.2026.1631123, PDF,    科研立项经费支持
作者: 赵思静:重庆医科大学附属口腔医院口腔颌面外科,重庆;口腔疾病与生物医学重庆市重点实验室,重庆;重庆市高校市级口腔生物医学工程重点实验,重庆;重庆市卫生健康委口腔生物医学工程重点实验室,重庆;季 平*:重庆医科大学附属永川医院口腔医学中心,重庆;翟启明*:口腔疾病与生物医学重庆市重点实验室,重庆;重庆市高校市级口腔生物医学工程重点实验,重庆;重庆市卫生健康委口腔生物医学工程重点实验室,重庆
关键词: 三羧酸循环骨代谢线粒体炎症代谢重编程TCA Cycle Bone Metabolism Mitochondria Inflammation Metabolic Reprogramming
摘要: 炎症性骨病是一种以持续的免疫激活和骨代谢失衡为特点的慢性炎症性疾病。越来越多的证据表明,免疫细胞和骨相关细胞的代谢状态是骨的吸收与形成改变的基础,决定着骨代谢趋势。代谢变化可以影响能量供应、细胞生物合成、信号传递和表观遗传调控,从而在一定程度上影响炎症性骨病的发生发展和结局。线粒体三羧酸循环(The tricarboxylic acid cycle)作为细胞代谢的引擎,一直被认为是一个经典的能量供应单元。最近对代谢重编程的研究极大地扩展了我们对TCA循环在信号转导、生物合成和细胞命运决定中的关键调控作用的理解。因此,针对TCA循环的关键酶及代谢物来治疗炎症性骨病是值得关注的。本综述旨在通过讨论TCA循环相关因素来阐明对其在炎症性骨病中的最新认识,从而强调TCA循环介导的代谢重编程所发挥的关键作用,并探索其作为治疗靶点的潜力。
Abstract: Inflammatory bone diseases are chronic inflammatory conditions characterized by sustained immune activation and imbalances in bone metabolism. A growing body of evidence indicates that the metabolic states of immune cells and bone-related cells underlie alterations in bone resorption and formation, shaping the overall trend of bone metabolism. Metabolic changes can influence energy supply, cellular biosynthesis, signal transduction, and epigenetic regulation, thereby playing a significant role in the pathogenesis, progression, and outcomes of inflammatory bone diseases. The mitochondrial tricarboxylic acid (TCA) cycle, often regarded as the engine of cellular metabolism, has long been recognized as a classic energy-producing unit. Recent studies on metabolic reprogramming have greatly expanded our understanding of the critical regulatory roles of the TCA cycle in signal transduction, biosynthesis, and cell fate determination. Therefore, targeting key enzymes and metabolites of the TCA cycle presents a promising therapeutic approach for inflammatory bone diseases. This review aims to elucidate the latest insights into the role of TCA cycle‑related factors in inflammatory bone diseases, highlighting the pivotal function of TCA cycle‑mediated metabolic reprogramming and exploring its potential as a therapeutic target.
文章引用:赵思静, 季平, 翟启明. TCA循环重编程:炎症性骨病中骨代谢紊乱的关键机制及治疗靶点[J]. 临床医学进展, 2026, 16(3): 3175-3183. https://doi.org/10.12677/acm.2026.1631123

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