基于子午流注理论探讨变应性鼻炎晨晚症状 加重的机制

Mechanistic Exploration on Exacerbation of Allergic Rhinitis Symptoms in the Morning and Evening Based on the Midnight-Noon Ebb and Flow Theory

摘要: 变应性鼻炎(allergic rhinitis, AR)是临床的常见病、难治病，大多数患者存在晨起、晚间症状加重的时间节律特征，该特征的机制阐释对AR的精准防治具有重要意义。通过梳理子午流注的理论内涵与AR现代生物医学机制的相关性，认为子午流注理论阐释的人体气血流注节律与现代生物钟研究存在显著相关性。从生物钟基因表达、神经–免疫网络调控、炎症介质节律波动、内分泌节律异常等层面，论证子午流注时辰节律与现代生物学机制的内在统一性。本文以子午流注理论为切入点，结合现代临床研究成果，探讨AR晨晚症状加重的核心机制，以中医理论与现代生物学结合的角度，阐释了AR晨晚症状加重的内在机制，以期为中西医结合治疗AR提供新的参考。

Abstract: Allergic rhinitis (AR) is a common and refractory clinical nasal disorder, with most patients exhibiting a distinct temporal rhythm of aggravated symptoms in the early morning and evening. Elucidating the mechanism of this rhythmic characteristic is crucial for the precise prevention and treatment of AR. The Midnight-Noon Ebb-Flow (MNEF) theory, which describes the circadian flow of qi and blood in the human body, is significantly correlated with modern circadian clock research. This study takes MNEF theory as the entry point, integrates modern clinical research findings, and demonstrates the intrinsic unity between the temporal rhythm of MNEF and the modern biological mechanisms of AR from the aspects of circadian clock gene expression, neuro-immune network regulation, rhythmic fluctuations of inflammatory mediators, and abnormal endocrine rhythms. This article takes the midnight-noon ebb-flow theory as its starting point and combines it with the results of modern clinical research to explore the core mechanism of the aggravation of morning and evening symptoms in acute rheumatoid arthritis (AR). It elucidates the internal mechanism of the aggravation of morning and evening symptoms in AR from the perspective of combining traditional Chinese medicine theory with modern biology, in order to provide a new reference for the integrated treatment of AR by traditional Chinese and Western medicine.