富血小板血浆治疗膝关节骨关节炎的研究进展
Recent Advances in Platelet-Rich Plasma Therapy for Knee Osteoarthritis
摘要: 膝关节骨关节炎(knee osteoarthritis, KOA)是一种以关节软骨进行性退变、软骨下骨重塑异常及滑膜炎症为特征的常见致残性退行性关节疾病。其治疗策略主要包括保守治疗(如物理治疗、药物治疗、注射治疗)和手术治疗。近年来，以富血小板血浆(platelet-rich plasma, PRP)为代表的再生医学疗法因其潜在的抗炎、修复和再生能力，在KOA治疗领域受到广泛关注。本文旨在系统综述PRP治疗KOA的作用机制、临床疗效、制备标准化问题及未来研究方向，为临床实践和科学研究提供循证依据和理论指导。
Abstract: Knee osteoarthritis (KOA) is a prevalent disabling degenerative joint disease characterized by progressive articular cartilage degeneration, aberrant subchondral bone remodeling, and synovial inflammation. Current management strategies primarily encompass conservative treatments (e.g., physical therapy, pharmacotherapy, and intra-articular injections) and surgical intervention. In recent years, regenerative medicine therapies, particularly platelet-rich plasma (PRP), have garnered significant attention in the field of KOA treatment due to their potential anti-inflammatory, reparative, and regenerative properties. This review aims to systematically summarize the mechanisms of action, clinical efficacy, standardization of preparation, and future research directions of PRP for KOA, thereby providing an evidence-based foundation and theoretical guidance for clinical practice and scientific research.
文章引用：钱致衡, 安昆, 呼星谷, 李红富, 刘俊飞, 吴佳铭, 向家乾, 赵刚. 富血小板血浆治疗膝关节骨关节炎的研究进展[J]. 临床医学进展, 2026, 16(3): 3349-3357. https://doi.org/10.12677/acm.2026.1631140

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