帕金森病抑郁、偏侧起病及脑白质变化的 关系：研究现状与展望

Relationships among Depression in Parkinson’s Disease, Lateralized Onset and Brain White Matter Changes: Current Research and Prospects

摘要: 帕金森病抑郁患病率高，但诊治不足，严重影响患者的生活质量及疾病预后。不同起病侧的帕金森病患者脑白质改变不同，患者的抑郁易感性及严重程度亦不同，但帕金森病抑郁、偏侧起病及脑白质变化三者之间的具体关联尚不明确。本文综述了帕金森病抑郁、偏侧起病及脑白质变化的相关研究进展，旨在探究三者之间的潜在关联，并提出未来将偏侧起病纳入帕金森病抑郁研究临床分层的可操作性及必要性，以期为帕金森病抑郁的白质改变相关机制提供更多的见解。

Abstract: The prevalence of depression in Parkinson’s disease (DPD) is high, yet its diagnosis and treatment remain inadequate, which severely impairs patients’ quality of life and affects disease prognosis. Brain white matter (WM) changes differ between PD patients with different onset sides, and they also show different degrees of depression vulnerability and severity. However, the specific relationship among DPD, lateralized onset, and brain WM changes remains unclear. In this review, we summarize recent advances on DPD, unilateral onset and brain WM changes. We explore potential associations among these three factors and propose the feasibility and necessity of integrating unilateral onset into clinical stratification for DPD-related studies. The goal is to provide further insights into the mechanisms underlying WM changes associated with DPD.