学龄前儿童的睡眠障碍与精神行为问题的研究进展
Research Progress on Sleep Disorders and Psycho-Behavioral Problems in Preschool Children
DOI: 10.12677/acm.2026.1631174, PDF,   
作者: 徐 颖*, 黄瑀涵:重庆医科大学附属儿童医院麻醉科,国家儿童青少年健康与疾病临床研究中心,教育部儿童发育与疾病重点实验室,重庆市儿童神经发育与认知障碍重点实验室,重庆
关键词: 睡眠障碍学龄前儿童精神行为问题内化与外化症状关联机制Sleep Disorders Preschool Children Psycho-Behavioral Problems Internalizing and Externalizing Symptoms Association Mechanism
摘要: 学龄前期是睡眠结构成熟化与精神心理发育塑型的关键窗口期,二者呈现双向调控、相互影响的动态关联。正常的睡眠结构与时长是精神心理发育的生理基础。现有临床研究证实,学龄前睡眠异常与情绪障碍、行为问题、社交发育异常密切相关,且其影响具有累积性,若未及时干预,部分异常表现会延续至学龄期甚至青少年期。本文依据国际睡眠障碍分类,系统梳理学龄前儿童的主要睡眠障碍类型、流行病学与核心临床特征,探讨不同类型睡眠障碍的潜在机制,分析其与精神行为问题之间可能的内在关联,为更深入地理解儿童睡眠障碍的潜在机制提供线索,并总结常见的干预策略,为临床精准防控儿童及青少年人群的精神心理疾病及基础研究探寻新的方向。
Abstract: The preschool period represents a critical window for the maturation of sleep architecture and the shaping of psychosocial development, with these two processes exhibiting a dynamic association of bidirectional regulation and mutual influence. Normal sleep architecture and duration serve as the physiological foundation for psychosocial development. Current clinical studies have confirmed that sleep abnormalities in preschool children are closely associated with emotional disorders, behavioral problems and social developmental anomalies in childhood, and the resulting impairments are cumulative. Without timely intervention, some abnormalities may persist into school age and even adolescence. Based on the International Classification of Sleep Disorders, this paper systematically reviews the main types, epidemiology and core clinical features of various sleep disorders in preschool children, explores the potential mechanisms underlying different types of sleep disorders, and analyzes the possible intrinsic associations with psycho-behavioral problems. It aims to provide clues for a deeper understanding of the potential mechanisms of childhood sleep disorders, and summarize common intervention strategies, so as to explore new directions for the clinical precise prevention and control of psycho-behavioral disorders in children and adolescents as well as basic research.
文章引用:徐颖, 黄瑀涵. 学龄前儿童的睡眠障碍与精神行为问题的研究进展[J]. 临床医学进展, 2026, 16(3): 3657-3668. https://doi.org/10.12677/acm.2026.1631174

参考文献

[1] Ednick, M., Cohen, A.P., McPhail, G.L., Beebe, D., Simakajornboon, N. and Amin, R.S. (2009) A Review of the Effects of Sleep during the First Year of Life on Cognitive, Psychomotor, and Temperament Development. Sleep, 32, 1449-1458. [Google Scholar] [CrossRef] [PubMed]
[2] Meneo, D., Gavriloff, D., Cerolini, S., Baldi, E., Schlarb, A., Nobili, L., et al. (2025) A Closer Look at Paediatric Sleep: Sleep Health and Sleep Behavioural Disorders in Children and Adolescents. Journal of Sleep Research, 34, e70078. [Google Scholar] [CrossRef] [PubMed]
[3] Drakatos, P., Marples, L., Muza, R., Higgins, S., Nesbitt, A., Dongol, E.M., et al. (2018) Video Polysomnographic Findings in Non‐Rapid Eye Movement Parasomnia. Journal of Sleep Research, 28, e12772. [Google Scholar] [CrossRef] [PubMed]
[4] Deng, Y., Zhang, Z., Gui, Y., Li, W., Rong, T., Jiang, Y., et al. (2023) Sleep Disturbances and Emotional and Behavioral Difficulties among Preschool-Aged Children. JAMA Network Open, 6, e2347623. [Google Scholar] [CrossRef] [PubMed]
[5] Cooper, R., Di Biase, M.A., Bei, B., Quach, J. and Cropley, V. (2023) Associations of Changes in Sleep and Emotional and Behavioral Problems from Late Childhood to Early Adolescence. JAMA Psychiatry, 80, 585-596. [Google Scholar] [CrossRef] [PubMed]
[6] Sateia, M.J. (2014) International Classification of Sleep Disorders-Third Edition: Highlights and Modifications. Chest, 146, 1387-1394. [Google Scholar] [CrossRef] [PubMed]
[7] Alfano, C.A. and Gamble, A.L. (2009) The Role of Sleep in Childhood Psychiatric Disorders. Child & Youth Care Forum, 38, 327-340. [Google Scholar] [CrossRef] [PubMed]
[8] Quach, J.L., Nguyen, C.D., Williams, K.E. and Sciberras, E. (2018) Bidirectional Associations between Child Sleep Problems and Internalizing and Externalizing Difficulties from Preschool to Early Adolescence. JAMA Pediatrics, 172, e174363. [Google Scholar] [CrossRef] [PubMed]
[9] Yelov, L., Reiter, J., Meira E Cruz, M. and Gileles-Hillel, A. (2024) The Association of Obstructive Sleep Apnea and Behavioral Insomnia in Children Ages 10 and Under. Journal of Clinical Sleep Medicine, 20, 245-251. [Google Scholar] [CrossRef] [PubMed]
[10] Mindell, J.A. and Meltzer, L.J. (2008) Behavioural Sleep Disorders in Children and Adolescents. Annals of the Academy of Medicine, Singapore, 37, 722-728. [Google Scholar] [CrossRef
[11] Carter, K.A., Hathaway, N.E. and Lettieri, C.F. (2014) Common Sleep Disorders in Children. American Family Physician, 89, 368-377.
[12] AlEidan, A., Al-Shamrani, M., AlGhofaily, M., AlDraiweesh, N., AlGhamdi, B., AlHabshan, H., et al. (2023) Prevalence of Sleep Problems and Habits among Children in Saudi Arabia: A Cross-Sectional Study. Saudi Medical Journal, 44, 289-295. [Google Scholar] [CrossRef] [PubMed]
[13] Owens, J.A. and Mindell, J.A. (2011) Pediatric Insomnia. Pediatric Clinics of North America, 58, 555-569. [Google Scholar] [CrossRef] [PubMed]
[14] Hiscock, H. and Wake, M. (2002) Randomised Controlled Trial of Behavioural Infant Sleep Intervention to Improve Infant Sleep and Maternal Mood. BMJ, 324, 1062-1065. [Google Scholar] [CrossRef] [PubMed]
[15] Reynaud, E., Vecchierini, M., Heude, B., Charles, M. and Plancoulaine, S. (2017) Sleep and Its Relation to Cognition and Behaviour in Preschool‐Aged Children of the General Population: A Systematic Review. Journal of Sleep Research, 27, e12636. [Google Scholar] [CrossRef] [PubMed]
[16] Williamson, A.A., Zendarski, N., Lange, K., Quach, J., Molloy, C., Clifford, S.A., et al. (2020) Sleep Problems, Internalizing and Externalizing Symptoms, and Domains of Health-Related Quality of Life: Bidirectional Associations from Early Childhood to Early Adolescence. Sleep, 44, zsaa139. [Google Scholar] [CrossRef] [PubMed]
[17] Masoud, A.I. and Mosli, R.H. (2023) Arabic Translation and Validation of a Pediatric Sleep Questionnaire to Assess the Prevalence of Sleep-Disordered Breathing among Saudi Pre-School Children. BMC Pediatrics, 23, Article No. 50. [Google Scholar] [CrossRef] [PubMed]
[18] van Eeden, C., Tamana, S.K., Narang, I., Hammam, N., Chikuma, J., Lefebvre, D.L., et al. (2021) Development and Validation of Sdbeasy Score as a Predictor of Behavioral Outcomes in Childhood. American Journal of Respiratory and Critical Care Medicine, 203, 718-725. [Google Scholar] [CrossRef] [PubMed]
[19] Csábi, E., Gaál, V., Hallgató, E., Schulcz, R.A., Katona, G. and Benedek, P. (2022) Increased Behavioral Problems in Children with Sleep-Disordered Breathing. Italian Journal of Pediatrics, 48, Article No. 173. [Google Scholar] [CrossRef] [PubMed]
[20] Isaiah, A., Teplitzky, T.B., Dontu, P., Saini, S., Som, M., Pereira, K.D., et al. (2023) Resting‐State Cerebral Hemodynamics Is Associated with Problem Behaviors in Pediatric Sleep‐disordered Breathing. OtolaryngologyHead and Neck Surgery, 169, 1290-1298. [Google Scholar] [CrossRef] [PubMed]
[21] Isaiah, A., Ernst, T., Cloak, C.C., Clark, D.B. and Chang, L. (2021) Associations between Frontal Lobe Structure, Parent-Reported Obstructive Sleep Disordered Breathing and Childhood Behavior in the ABCD Dataset. Nature Communications, 12, Article No. 2205. [Google Scholar] [CrossRef] [PubMed]
[22] Zaffanello, M., Ferrante, G., Zoccante, L., Ciceri, M., Nosetti, L., Tenero, L., et al. (2023) Predictive Power of Oxygen Desaturation Index (ODI) and Apnea-Hypopnea Index (AHI) in Detecting Long-Term Neurocognitive and Psychosocial Outcomes of Sleep-Disordered Breathing in Children: A Questionnaire-Based Study. Journal of Clinical Medicine, 12, Article 3060. [Google Scholar] [CrossRef] [PubMed]
[23] Zhang, W., Shen, Y., Ou, X., Wang, H. and Liu, S. (2024) Sleep Disordered Breathing and Neurobehavioral Deficits in Children and Adolescents: A Systematic Review and Meta-Analysis. BMC Pediatrics, 24, Article No. 70. [Google Scholar] [CrossRef] [PubMed]
[24] Tsou, P., Gueye-Ndiaye, S., Gorman, K.L., Williamson, A., Ibrahim, S., Weber, S., et al. (2024) Asthma and Sleep Disordered Breathing in the Pediatric Adenotonsillectomy Trial for Snoring Study. Sleep and Breathing, 29, Article No. 46. [Google Scholar] [CrossRef] [PubMed]
[25] Ersu, R., Arman, A.R., Save, D., Karadag, B., Karakoc, F., Berkem, M., et al. (2004) Prevalence of Snoring and Symptoms of Sleep-Disordered Breathing in Primary School Children in Istanbul. Chest, 126, 19-24. [Google Scholar] [CrossRef] [PubMed]
[26] Gibson, P.G. and McDonald, V.M. (2024) Integrating Hot Topics and Implementation of Treatable Traits in Asthma. European Respiratory Journal, 64, Article ID: 2400861. [Google Scholar] [CrossRef] [PubMed]
[27] Pressman, M.R. and Bornemann, M.C. (2015) The ICSD-3 NREM Parasomnia Section Is Evidence Based Resulting from International Collaboration, Consensus and Best Practices. Journal of Clinical Sleep Medicine, 11, 187-188. [Google Scholar] [CrossRef] [PubMed]
[28] Gigliotti, F., Esposito, D., Basile, C., Cesario, S. and Bruni, O. (2021) Sleep Terrors—A Parental Nightmare. Pediatric Pulmonology, 57, 1869-1878. [Google Scholar] [CrossRef] [PubMed]
[29] Laganière, C., Gaudreau, H., Pokhvisneva, I., Kenny, S., Bouvette-Turcot, A., Meaney, M., et al. (2022) Sleep Terrors in Early Childhood and Associated Emotional–behavioral Problems. Journal of Clinical Sleep Medicine, 18, 2253-2260. [Google Scholar] [CrossRef] [PubMed]
[30] Brion, A. (2021) [Practice Guide for the Management of Nightmare Disorders]. La Revue du Praticien, 71, 1001-1006.
[31] Scarpelli, S., Bartolacci, C., D’Atri, A., Gorgoni, M. and De Gennaro, L. (2019) Mental Sleep Activity and Disturbing Dreams in the Lifespan. International Journal of Environmental Research and Public Health, 16, Article 3658. [Google Scholar] [CrossRef] [PubMed]
[32] Duffy, J.F., Abbott, S.M., Burgess, H.J., Crowley, S.J., Emens, J.S., Epstein, L.J., et al. (2021) Workshop Report. Circadian Rhythm Sleep-Wake Disorders: Gaps and Opportunities. Sleep, 44, zsaa281. [Google Scholar] [CrossRef] [PubMed]
[33] Wichniak, A., Jankowski, K., Skalski, M., Skwarło-Sońta, K., Zawilska, J., Żarowski, M., et al. (2017) Treatment Guidelines for Circadian Rhythm Sleep—Wake Disorders of the Polish Sleep Research Society and the Section of Biological Psychiatry of the Polish Psychiatric Association. Part II. Diagnosis and Treatment. Psychiatria Polska, 51, 815-832. [Google Scholar] [CrossRef] [PubMed]
[34] Murray, J.M., Sletten, T.L., Magee, M., Gordon, C., Lovato, N., Bartlett, D.J., Kennaway, D.J., Lack, L.C., Grunstein, R.R., Lockley, S.W. and Rajaratnam, S.M. (2017) Prevalence of Circadian Misalignment and Its Association with De-pressive Symptoms in Delayed Sleep Phase Disorder. Sleep, 40, zsw002. [Google Scholar] [CrossRef] [PubMed]
[35] 沈碧玉, 樊盼玉, 王新红, 等. 危重症患儿睡眠与昼夜节律的范围综述[C]//上海市护理学会. 第六届上海国际护理大会论文汇编(中). 2024: 170-171.
[36] 胡馨雨. 电针通过RORα通路调节昼夜节律改善帕金森病的神经炎症和运动障碍[C]//中国睡眠研究会. 中国睡眠研究会第16届全国学术年会暨湖北科学技术学术年会论文汇编. 武汉: 华中科技大学同济医学院附属协和医院, 2024: 376.
[37] 吴新顺, 李劲草, 刘影, 等. 大麻二酚通过调节昼夜节律改善大鼠全麻术后的睡眠障碍[J]. 南方医科大学学报, 2025, 45(4): 744-750.
https://link.cnki.net/urlid/44.1627.r.20250425.1102.050
[38] Gogo, E., van Sluijs, R.M., Cheung, T., Gaskell, C., Jones, L., Alwan, N.A., et al. (2019) Objectively Confirmed Prevalence of Sleep-Related Rhythmic Movement Disorder in Pre-School Children. Sleep Medicine, 53, 16-21. [Google Scholar] [CrossRef] [PubMed]
[39] Laganière, C., Gaudreau, H., Pokhvisneva, I., Atkinson, L., Meaney, M. and Pennestri, M. (2018) Maternal Characteristics and Behavioural/Emotional Problems in Preschoolers: How They Relate to Sleep Rhythmic Movements at Sleep Onset. Journal of Sleep Research, 28, e12707. [Google Scholar] [CrossRef] [PubMed]
[40] Armstrong, J.M., Ruttle, P.L., Klein, M.H., Essex, M.J. and Benca, R.M. (2014) Associations of Child Insomnia, Sleep Movement, and Their Persistence with Mental Health Symptoms in Childhood and Adolescence. Sleep, 37, 901-909. [Google Scholar] [CrossRef] [PubMed]
[41] Merli, E., Ferri, R., DelRosso, L.M., Mignani, F., Loddo, G., Traverso, A., et al. (2019) Sleep-Related Rhythmic Movements and Sleep Terrors: A Possible Common Neurophysiological Background in a Preschool Boy. Journal of Clinical Sleep Medicine, 15, 1849-1852. [Google Scholar] [CrossRef] [PubMed]
[42] Wang, Y., Chen, Y., Tong, Y., Li, C., Li, J. and Wang, X. (2022) Heterogeneity in Estimates of Incidence and Prevalence of Narcolepsy: A Systematic Review and Meta-Regression Analysis. Neuroepidemiology, 56, 319-332. [Google Scholar] [CrossRef] [PubMed]
[43] Motomura, Y., Kitamura, S., Oba, K., Terasawa, Y., Enomoto, M., Katayose, Y., et al. (2013) Sleep Debt Elicits Negative Emotional Reaction through Diminished Amygdala-Anterior Cingulate Functional Connectivity. PLOS ONE, 8, e56578. [Google Scholar] [CrossRef] [PubMed]
[44] Toh, K.L. (2008) Basic Science Review on Circadian Rhythm Biology and Circadian Sleep Disorders. Annals of the Academy of Medicine, Singapore, 37, 662-668. [Google Scholar] [CrossRef
[45] Kramer, A., Lange, T., Spies, C., Finger, A., Berg, D. and Oster, H. (2022) Foundations of Circadian Medicine. PLOS Biology, 20, e3001567. [Google Scholar] [CrossRef] [PubMed]
[46] Gomes, K. and Goldman, R.D. (2024) Screen Time and Sleep in Children. Canadian Family Physician, 70, 388-390. [Google Scholar] [CrossRef] [PubMed]
[47] Nishioka, T., Hasunuma, H., Okuda, M., Taniguchi, N., Fujino, T., Shimomura, H., et al. (2022) Effects of Screen Viewing Time on Sleep Duration and Bedtime in Children Aged 1 and 3 Years: Japan Environment and Children’s Study. International Journal of Environmental Research and Public Health, 19, Article 3914. [Google Scholar] [CrossRef] [PubMed]
[48] Higuchi, S., Nagafuchi, Y., Lee, S. and Harada, T. (2014) Influence of Light at Night on Melatonin Suppression in Children. The Journal of Clinical Endocrinology & Metabolism, 99, 3298-3303. [Google Scholar] [CrossRef] [PubMed]
[49] Akacem, L.D., Wright, K.P. and LeBourgeois, M.K. (2016) Bedtime and Evening Light Exposure Influence Circadian Timing in Preschool-Age Children: A Field Study. Neurobiology of Sleep and Circadian Rhythms, 1, 27-31. [Google Scholar] [CrossRef] [PubMed]
[50] Kok, E.Y., Kaur, S., Mohd Shukri, N.H., Abdul Razak, N., Takahashi, M., Teoh, S.C., et al. (2024) The Role of Light Exposure in Infant Circadian Rhythm Establishment: A Scoping Review Perspective. European Journal of Pediatrics, 184, Article No. 112. [Google Scholar] [CrossRef] [PubMed]
[51] (2024) 2024 Society of Pediatric Psychology Annual Conference Abstracts: What’s Next? Defining the Path Forward for Pediatric Psychology. Journal of Pediatric Psychology, 49, jsae010. [Google Scholar] [CrossRef] [PubMed]
[52] Ameen, R.W., Warshawski, A., Fu, L. and Antle, M.C. (2022) Early Life Circadian Rhythm Disruption in Mice Alters Brain and Behavior in Adulthood. Scientific Reports, 12, Article No. 7366. [Google Scholar] [CrossRef] [PubMed]
[53] Yang, Z., Williams, S.D., Beldzik, E., Anakwe, S., Schimmelpfennig, E. and Lewis, L.D. (2025) Attentional Failures after Sleep Deprivation Are Locked to Joint Neurovascular, Pupil and Cerebrospinal Fluid Flow Dynamics. Nature Neuroscience, 28, 2526-2536. [Google Scholar] [CrossRef
[54] Chang, J.P., Su, K., Mondelli, V. and Pariante, C.M. (2021) Cortisol and Inflammatory Biomarker Levels in Youths with Attention Deficit Hyperactivity Disorder (ADHD): Evidence from a Systematic Review with Meta-Analysis. Translational Psychiatry, 11, Article No. 430. [Google Scholar] [CrossRef] [PubMed]
[55] Chao, Y., Wang, Y., Yang, J., Guo, K., Ma, K., Ding, P., et al. (2022) Associations of Social Jetlag and Emotional and Behavioral Problems among Chinese Preschoolers. Chronobiology International, 39, 1110-1117. [Google Scholar] [CrossRef] [PubMed]
[56] 刘登峰, 张逸淳, 李家大. 昼夜节律紊乱与神经发育障碍[J]. 生理学报, 2025, 77(4): 678-688. [Google Scholar] [CrossRef] [PubMed]
[57] Gershoff, E.T. (2002) Corporal Punishment by Parents and Associated Child Behaviors and Experiences: A Meta-Analytic and Theoretical Review. Psychological Bulletin, 128, 539-579. [Google Scholar] [CrossRef] [PubMed]
[58] 薛旭升, 贾甜, 杨琳. 家庭养育方式与儿童睡眠状况关系分析[J]. 中国儿童保健杂志, 2022, 30(11): 1237-1240, 1271.
https://link.cnki.net/urlid/61.1346.R.20221017.1427.020
[59] Huang, M., Wang, D., Zhang, Y., Li, M., Li, H., Zhang, X., et al. (2025) The Association of Parental Insomnia Symptoms with Adolescent Insomnia and Depressive Symptoms: A Child-Parent Dyad Study. Sleep Medicine, 128, 103-109. [Google Scholar] [CrossRef] [PubMed]
[60] Guner, N. and Hayton, J.A. (2024) Parental and Child Sleep: Children with Vision Impairment, Autistic Children, and Children with Comorbid Vision Impairment and Autism. Brain Sciences, 14, Article 485. [Google Scholar] [CrossRef] [PubMed]
[61] Goel, P. and Goel, A. (2024) Exploring the Evolution of Sleep Patterns from Infancy to Adolescence. Cureus, 16, e64759. [Google Scholar] [CrossRef] [PubMed]
[62] Troxel, W.M., Haas, A., Ghosh-Dastidar, B., Holliday, S.B., Richardson, A.S., Schwartz, H., et al. (2020) Broken Windows, Broken ZZs: Poor Housing and Neighborhood Conditions Are Associated with Objective Measures of Sleep Health. Journal of Urban Health, 97, 230-238. [Google Scholar] [CrossRef] [PubMed]
[63] Trickett, J., Hill, C., Austin, T. and Johnson, S. (2022) The Impact of Preterm Birth on Sleep through Infancy, Childhood and Adolescence and Its Implications. Children, 9, Article 626. [Google Scholar] [CrossRef] [PubMed]
[64] Donovan, C.L., Shiels, A., Legg, M., Meltzer, L.J., Farrell, L.J., Waters, A.M., et al. (2023) Treating Sleep Problems in Young Children: A Randomised Controlled Trial of a Group-Based, Parent-Focused Behavioural Sleep Intervention. Behaviour Research and Therapy, 167, Article ID: 104366. [Google Scholar] [CrossRef] [PubMed]
[65] Barron-Linnankoski, S.T.A., Raaska, H.K., Reiterä, P.H., Laasonen, M.R. and Elovainio, M.J. (2024) Hair Cortisol and Psychiatric Symptomatology in Children; Outcomes of Group CBT. Comprehensive Psychoneuroendocrinology, 20, Article ID: 100263. [Google Scholar] [CrossRef] [PubMed]
[66] Dimakos, J., Gauthier-Gagné, G., Lin, L., Scholes, S. and Gruber, R. (2024) The Associations between Sleep and Externalizing and Internalizing Problems in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: Empirical Findings, Clinical Implications, and Future Research Directions. Psychiatric Clinics of North America, 47, 179-197. [Google Scholar] [CrossRef] [PubMed]
[67] Dolsen, E.A., Asarnow, L.D. and Harvey, A.G. (2014) Insomnia as a Transdiagnostic Process in Psychiatric Disorders. Current Psychiatry Reports, 16, Article No. 471. [Google Scholar] [CrossRef] [PubMed]
[68] Arns, M., Kooij, J.J.S. and Coogan, A.N. (2021) Review: Identification and Management of Circadian Rhythm Sleep Disorders as a Transdiagnostic Feature in Child and Adolescent Psychiatry. Journal of the American Academy of Child & Adolescent Psychiatry, 60, 1085-1095. [Google Scholar] [CrossRef] [PubMed]