多原发恶性肿瘤(甲状腺乳头状癌与恶性黑色素瘤) 1例

A Case Report of Multiple Primary Neoplasms: Papillary Thyroid Carcinoma Combined with Malignant Melanoma

摘要: 多原发恶性肿瘤(Multiple primary neoplasms, MPNs)在临床上的发病情况极为罕见，我国MPNs的发病率约0.60%~2.67%。MPNs的诊断与治疗对于临床医生来说均是极具挑战性的难题。本文现报道1例50岁女性患者，其被同步诊断为甲状腺乳头状癌与恶性黑色素瘤，且伴有全身多处区域淋巴结转移。本文结合患者的临床资料、病变组织形态学特征以及免疫组化结果，对相关文献进行复习，分析该类病例的发病特点与诊疗进展，旨在为临床病理医师的诊断工作以及临床治疗方案的制定提供参考，同时丰富该类病例的临床病理资料。

Abstract: Multiple primary neoplasms (MPNs) are extremely rare in clinical practice. The incidence of MPNs in China is approximately 0.60% to 2.67%. The diagnosis and treatment of MPNs present significant challenges for clinicians. This paper reports the case of a 50-year-old female patient who was concurrently diagnosed with papillary thyroid carcinoma and malignant melanoma, accompanied by multiple regional lymph node metastases throughout the body. Based on the integration of the patient’s clinical data, morphological characteristics of the lesional tissue, and immunohistochemistry findings, this study reviews the relevant literature and conducts an in-depth analysis of the clinical features, diagnosis, and therapeutic advancements in this category of cases. The objective is to provide valuable insights to support diagnostic practices for clinical pathologists and inform the formulation of treatment strategies, while also contributing to the enrichment of clinicopathological documentation for such cases.