锶调控骨代谢机制的研究进展
Research Progress on the Mechanisms by Which Strontium Regulates Bone Metabolism
DOI: 10.12677/acm.2026.1631185, PDF,   
作者: 熊缄琦, 刘雁鸣*:浙江大学医学院附属第二医院口腔颌面外科,浙江 杭州
关键词: 骨代谢钙离子敏感受体Bone Metabolism Strontium Calcium Ion-Sensitive Receptor
摘要: 锶作为一种与钙在化学性质上高度相似的元素,在骨代谢调控和骨修复过程中表现出显著的促成骨和抑制骨吸收作用,已被广泛应用于抗骨质疏松治疗及骨组织工程材料的设计中。然而,锶调控骨代谢的分子机制复杂,涉及MAPK/ERK、PI3K/Akt、Wnt和NFATc1等多条信号通路,并且通路之间存在相互影响,本文总结了近年来关于锶调控骨代谢机制的研究。
Abstract: Strontium, an element highly similar to calcium in chemical properties, exhibits significant osteogenic and osteoresorption-inhibiting effects in bone metabolism regulation and bone repair, and has been widely used in osteoporosis treatment and the design of bone tissue engineering materials. However, the molecular mechanisms by which strontium regulates bone metabolism are complex, involving multiple signaling pathways such as MAPK/ERK, PI3K/Akt, Wnt, and NFATc1, and these pathways interact with each other. This article summarizes recent research on the mechanisms by which strontium regulates bone metabolism.
文章引用:熊缄琦, 刘雁鸣. 锶调控骨代谢机制的研究进展[J]. 临床医学进展, 2026, 16(3): 3770-3776. https://doi.org/10.12677/acm.2026.1631185

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