NRG2对肝细胞癌患者预后的影响及其 作用机制

The Impact of NRG2 on Prognosis in Hepatocellular Carcinoma Patients and Its Mechanism of Action

摘要: NRG2 (Neuregulin 2，神经调节蛋白2)作为表皮生长因子家族成员，在多种恶性肿瘤中异常表达，且与肿瘤增殖、侵袭转移及患者预后密切相关。肝细胞癌(HCC)是常见的恶性肿瘤，本文通过使用癌症基因组图谱(TCGA)数据库分析NRG2在肝癌中的表达及通过进行基因富集分析(GSEA)研究NRG2相关基因可能参与的HCC相关信号通路，通过使用HPA数据库获得NRG2蛋白表达数据，分析NRG2在HCC可能起到的作用，通过使用Kaplan-Meier分析其预后价值，最后得知，NRG2在HCC中高表达，其高表达提示预后不良，可能与NRG2参与细胞增殖通路相关。

Abstract: NRG2 (Neuregulin 2), a member of the epidermal growth factor family, is aberrantly expressed in various malignant tumors and is closely associated with tumor proliferation, invasion, metastasis, and patient prognosis. Hepatocellular carcinoma (HCC) is a common malignant tumor. This study analyzed NRG2 expression in liver cancer using The Cancer Genome Atlas (TCGA) database and investigated NRG2-related genes and their potential involvement in HCC-associated signaling pathways through Gene Set Enrichment Analysis (GSEA). NRG2 protein expression data were obtained from the Human Protein Atlas (HPA) database to analyze the potential role of NRG2 in HCC. The prognostic value of NRG2 was evaluated using Kaplan-Meier analysis. The results demonstrated that NRG2 is highly expressed in HCC, and its elevated expression indicates poor prognosis, which may be associated with NRG2’s involvement in cell proliferation pathways.