小胶质细胞参与酒精使用障碍神经炎症的研究进展
Research Progress on the Role of Microglia in Neuroinflammation Associated with Alcohol Use Disorders
DOI: 10.12677/ojns.2026.142028, PDF,    科研立项经费支持
作者: 何 林*, 刘红艳, 马润娟#：昆明医科大学附属精神卫生中心，云南省精神病医院，云南 昆明
关键词: 酒精使用障碍；神经炎症；小胶质细胞；Alcohol Use Disorder； Neuroinflammation； Microglia
摘要: 酒精使用障碍是一种普遍存在的神经精神疾病，以焦虑、抑郁和认知功能障碍为其主要临床表现，给患者生活质量产生了巨大影响。酒精使用障碍的发病机理具有复杂性与多样性，现有研究证实，慢性神经炎症在该疾病的发生及进展过程中起到至关重要的作用。小胶质细胞作为常驻的免疫细胞，当受到酒精刺激时会发生激活，进而促使细胞因子、趋化因子以及活性氧等具有促炎性质的介质大量释放，进而引发神经炎症反应。因此，探讨小胶质细胞在酒精使用障碍中的作用机制，为酒精使用障碍相关作用机制的深入研究及临床防治、药物研发提供一定的参考和依据。
Abstract: Alcohol use disorder is a common neuro-psychiatric disease, with anxiety, depression and cognitive dysfunction as its main clinical manifestations, which has a significant impact on the quality of life of patients. The etiological mechanism of alcohol use disorder is complex and diverse. Studies have shown that chronic neuroinflammation plays a key role in its occurrence and development. Microglia, as resident immune cells, become activated when stimulated by alcohol, which leads to the massive release of pro-inflammatory mediators such as cytokines, chemokines, and reactive oxygen species, thereby triggering neuroinflammatory responses. Therefore, exploring the mechanism of microglia in alcohol use disorder provides certain references and basis for in-depth research on the related mechanisms of alcohol use disorder, clinical prevention and treatment, and drug development.
文章引用：何林, 刘红艳, 马润娟. 小胶质细胞参与酒精使用障碍神经炎症的研究进展[J]. 自然科学, 2026, 14(2): 248-254. https://doi.org/10.12677/ojns.2026.142028

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