维持性血液透析患者口渴症状的影响因素及干预措施:一项范围综述
Influencing Factors and Intervention Measures of Thirst Symptoms in Maintenance Hemodialysis Patients: A Scope Review
DOI: 10.12677/ns.2026.153097, PDF,    科研立项经费支持
作者: 葸英博:甘肃中医药大学附属医院护理部,甘肃 兰州;蔡 瑛:甘肃中医药大学附属医院宋氏正骨科,甘肃 兰州
关键词: 血液透析口渴影响因素干预措施范围综述Hemodialysis Thirst Influencing Factors Intervention Measures Scoping Review
摘要: 目的:本范围综述旨在全面梳理血液透析患者口渴症状的影响因素及干预措施相关研究。方法:基于范围综述框架,通过系统检索PubMed、Embase、Cochrane Library、CINAHL、Web of Science、知网、万方、维普及生物医学文献数据库,筛选有关血液透析患者口渴症状的文献,检索时限为建库至2025年5月30日,由两名研究者对纳入的文献进行数据提取及汇总分析。并进行分类整合。结果:最终纳入52篇文献,确定了多个与血液透析患者口渴相关的影响因素,包括高钠血症、口腔干燥、残存肾功能等生理因素、心理压力、焦虑抑郁情绪等心理因素、透析模式、透析液钠浓度等透析治疗因素,干预措施涵盖饮食调整、药物及非药物干预等多维度策略。结论:血液透析患者口渴受高钠血症、液体限制、心理压力、透析模式等多种因素共同作用,现有干预措施虽多样,但缺乏高质量证据支持。本综述为临床制定针对性口渴管理策略提供理论依据,同时为后续研究指明方向。
Abstract: Objective: This scoping review aims to comprehensively summarize the research on the influencing factors and intervention measures for thirst in hemodialysis patients. Methods: Based on the scoping review framework, a systematic search was conducted in PubMed, Embase, Cochrane Library, CINAHL, Web of Science, CNKI, Wanfang, VIP, and Biomedical Literature Database to screen relevant literature. The search period was from the establishment of the databases to May 30, 2025. Two researchers extracted and summarized the data from the included literature and classified and integrated them. Results: A total of 52 articles were included. Multiple factors related to thirst in hemodialysis patients were identified, including physiological factors such as hypernatremia and xerostomia, psychological factors such as psychological stress and anxiety and depression, and dialysis treatment factors such as dialysis mode and dialysate sodium concentration. Intervention measures included dietary, pharmacological, and non-pharmacological approaches. Conclusion: Thirst in hemodialysis patients is influenced by multiple factors such as hypernatremia, fluid restriction, psychological stress, and dialysis mode. Although there are various intervention measures, there is a lack of high-quality evidence to support them. This review provides a theoretical basis for the clinical development of targeted thirst management strategies and points out the direction for future research.
文章引用:葸英博, 蔡瑛. 维持性血液透析患者口渴症状的影响因素及干预措施:一项范围综述[J]. 护理学, 2026, 15(3): 305-313. https://doi.org/10.12677/ns.2026.153097

参考文献

[1] CNRDS中国研究数据服务平台[EB/OL].
http://www.cnrds.com, 2025-12-10.
[2] 祝凤桂, 陈洪宇, 林日阳. 血透患者口渴治疗临床研究进展[J]. 中国中西医结合肾病杂志, 2018, 19(10): 928-930.
[3] López-Pintor, R.M., López-Pintor, L., Casañas, E., et al. (2017) Risk Factors Associated with Xerostomia in Haemodialysis Patients. Medicina Oral Patología Oral y Cirugia Bucal, 22, e185-e192. [Google Scholar] [CrossRef] [PubMed]
[4] Leggat, J., Orzol, S., Hulbert-Shearon, T., Golper, T., Jones, C., Held, P., et al. (1998) Noncompliance in Hemodialysis: Predictors and Survival Analysis. American Journal of Kidney Diseases, 32, 139-145. [Google Scholar] [CrossRef] [PubMed]
[5] 李梅, 蔡小玲, 陈佳. 慢性心衰患者液体限制依从性差的危险因素分析[J]. 青岛医药卫生, 2023, 55(4): 276-278.
[6] Peters, M.D.J., Marnie, C., Tricco, A.C., Pollock, D., Munn, Z., Alexander, L., et al. (2020) Updated Methodological Guidance for the Conduct of Scoping Reviews. JBI Evidence Synthesis, 18, 2119-2126. [Google Scholar] [CrossRef] [PubMed]
[7] 范伟峰. 维持性血透患者口渴相关因素及干预的临床意义[D]: [硕士学位论文]. 上海: 复旦大学, 2009.
[8] 林日阳. 耳穴贴压治疗维持性血液透析患者口渴症的研究[D]: [硕士学位论文]. 北京: 北京中医药大学, 2008.
[9] 金霄, 李玉梅, 林日阳. 耳穴贴压治疗维持性血液透析患者口渴症23例[J]. 浙江中医杂志, 2009, 44(11): 827-828.
[10] 李亚伟. 清开灵口服液缓解血液透析患者口渴症状的疗效观察[D]: [硕士学位论文]. 北京: 北京中医药大学, 2009.
[11] 朱传馨. 耳穴贴压法治疗维持性血液透析患者口渴的疗效观察[D]: [硕士学位论文]. 武汉: 湖北中医药大学, 2010.
[12] 金晟, 龙利. 六味地黄丸治疗规律血液透析患者口干的临床疗效观察[J]. 湖北中医杂志, 2012, 34(3): 17.
[13] 李翔, 卢冰, 姜美娟. 益气养阴方治疗维持性血透患者口渴47例[J]. 浙江中医杂志, 2012, 47(1): 51.
[14] 王东峰. 单味中药乌梅对维持性血液透析患者透析间期体重的干预[D]: [硕士学位论文]. 北京: 北京中医药大学, 2012.
[15] 谢敏, 胡振奋. 耳穴治疗血液透析口渴患者90例及作用机理初探[J]. 中国中医药科技, 2012, 19(6): 538-539.
[16] 李飞, 宋树斌, 路建秋. 辨证分型治疗维持性血液透析口干症临床观察[J]. 实用中医内科杂志, 2013, 27(14): 69-70.
[17] 许红兰, 王芳芳. 自拟止渴方治疗血液透析患者疗效观察[J]. 长江大学学报(自科版), 2013, 10(24): 69-70.
[18] 张蕊. 耳穴疗法联合枸杞子治疗50例维持性血液透析患者的口渴症状[D]: [硕士学位论文]. 北京: 北京中医药大学, 2014.
[19] 陈小平, 陈建军, 王悦, 等. 中药内服外敷治疗维持性血液透析患者口干症疗效观察[J]. 浙江中医杂志, 2016, 51(7): 499.
[20] 刘鹏, 邱模炎, 段瑶, 等. 中药代茶饮改善血液透析患者口渴症状的临床研究[J]. 辽宁中医杂志, 2016, 43(12): 2548-2551.
[21] 樊映孜. 耳穴压丸法联合生脉胶囊改善46例MHD患者口渴的临床疗效观察[D]: [硕士学位论文]. 北京: 北京中医药大学, 2016.
[22] 冯慧玲. 耳穴联合针刺对维持性血液透析阳虚水湿型口渴患者的干预研究[D]: [硕士学位论文]. 成都: 成都中医药大学, 2016.
[23] 梁晖. 乌梅含漱液对维持性血液透析口渴患者的临床观察及唾液流率与相关因子研究[D]: [博士学位论文]. 广州: 广州中医药大学, 2016.
[24] 刘国香, 韩国锋, 王颖. 维持性血液透析患者口渴以及影响因素分析[J]. 中国中西医结合肾病杂志, 2016, 17(12): 1095-1097.
[25] 陶琼, 黄新艳. 滋阴益气活血膏治疗维持性血透口渴36例疗效观察[J]. 湖南中医杂志, 2016, 32(7): 10-12.
[26] 杨国文. 耳穴疗法对维持性血液透析患者口干及容量的影响[D]: [硕士学位论文]. 广州: 广州中医药大学, 2016.
[27] 郭小卫, 吴秀清, 钟志聪, 等. 自制中药含漱液对血液透析患者透析间期体重控制的初步探索[J]. 中国中西医结合肾病杂志, 2017, 18(9): 826-827.
[28] 叶景云, 张洁婷, 陈佩仪. 基于酸甘化阴理论乌梅喷雾剂改善血液透析患者口渴症的效果观察[J]. 护理学报, 2017, 24(20): 4-7.
[29] 曹钋, 刘福生, 任可, 等. 耳针压丸联合生脉胶囊改善血液透析患者口渴及低血压的多中心随机对照研究[J]. 中华中医药杂志, 2018, 33(9): 4213-4216.
[30] 程金凤, 吴秀清, 钟志聪, 等. 应用中药含漱液治疗血液透析患者口干症的护理[J]. 按摩与康复医学, 2018, 9(16): 77-78.
[31] 乔传勋, 韩朋辉, 徐静, 等. 穴位按摩联合柠檬水喷雾对全身麻醉下乳腺癌手术患者围手术期口渴程度的影响[J]. 临床研究, 2025, 33(10): 171-174.
[32] 李阿敏, 张海林, 尹丽霞, 等. 钠综合管理对维持性血液透析口渴患者干预效果的研究[J]. 临床肾脏病杂志, 2019, 19(9): 653-658.
[33] 夏苑莺, 赵俊, 娄成利, 等. 养阴生津活血颗粒方联合耳穴疗法治疗终末期肾脏病血液透析患者口渴的临床观察[J]. 中国现代医生, 2019, 57(4): 126-129.
[34] 祝凤桂. 耳穴按压缓解维持性血液透析患者口渴的随机对照研究[D]: [硕士学位论文]. 杭州: 浙江中医药大学, 2019.
[35] 程新, 胡江平, 罗方, 等. 针刺联合苓桂术甘汤对维持性血液透析患者口渴的影响[J]. 世界中医药, 2021, 16(9): 1472-1476.
[36] 费彩华, 徐颖, 王玉, 等. 耳穴压丸联合草珊瑚含片对血液透析患者口渴程度的分析与研究[J]. 江西医药, 2021, 56(9): 1403-1404+1407.
[37] 李书文, 孙娜婷, 张珂茹, 等. 敦煌含噙乌梅生脉饮治疗维持性血液透析患者口渴的临床观察[J]. 中医药学报, 2021, 49(5): 87-92.
[38] 邵碧云, 孟晓丽, 应金萍, 等. 维持性血液透析患者口渴现状调查及影响因素分析[J]. 护理与康复, 2021, 20(8): 69-72.
[39] 黄露露. 赤龙搅海运动处方改善维持性血液透析者口渴感的护理干预研究[D]: [硕士学位论文]. 兰州: 甘肃中医药大学, 2022.
[40] 吕锦旭, 刘金凤, 刘烨倩, 等. 维持性血液透析病人口渴现状及其影响因素调查研究[J]. 全科护理, 2022, 20(8): 1120-1123.
[41] 谢蓉蓉. 柠檬冰块在维持性血液透析口渴患者中的应用研究[D]: [硕士学位论文]. 南昌: 南昌大学, 2022.
[42] 陈文思, 张红梅. 维持性血液透析患者口渴现状及影响因素分析[J]. 中国血液净化, 2023, 22(1): 64-67.
[43] 连小勤, 关风光, 林如, 等. 茉莉花茶水浸液对维持性血液透析病人口渴感及口腔气味的效果研究[J]. 全科护理, 2023, 21(20): 2820-2823.
[44] 王月婷. 止渴喷剂治疗维持性血液透析气阴两虚证患者口渴的临床研究[D]: [硕士学位论文]. 武汉: 湖北中医药大学, 2024.
[45] 杨康怡. 穴位磁珠贴压对维持性血液透析患者口渴感的应用研究[D]: [硕士学位论文]. 长春: 长春中医药大学, 2024.
[46] 董钰, 刘佳, 李香娥, 等. 中药漱口联合耳穴埋针对维持性血液透析治疗患者口渴症状的改善情况[J]. 河北中医, 2025, 47(1): 114-118+124.
[47] 卢雯雯, 张迪, 刘雪纯, 等. 稀释风油精含漱液对血液透析口渴患者的干预效果研究[J]. 临床肾脏病杂志, 2025, 25(3): 222-226.
[48] Yang, L., Yates, P., Chin, C. and Kao, T. (2010) Effect of Acupressure on Thirst in Hemodialysis Patients. Kidney and Blood Pressure Research, 33, 260-265. [Google Scholar] [CrossRef] [PubMed]
[49] Jagodzińska, M., Zimmer-Nowicka, J. and Nowicki, M. (2011) Three Months of Regular Gum Chewing Neither Alleviates Xerostomia Nor Reduces Overhydration in Chronic Hemodialysis Patients. Journal of Renal Nutrition, 21, 410-417. [Google Scholar] [CrossRef] [PubMed]
[50] Fan, W., Zhang, Q., Luo, L., Niu, J. and Gu, Y. (2013) Study on the Clinical Significance and Related Factors of Thirst and Xerostomia in Maintenance Hemodialysis Patients. Kidney and Blood Pressure Research, 37, 464-474. [Google Scholar] [CrossRef] [PubMed]
[51] Marques, P.L.P., Libório, A.B. and de Lima Saintrain, M.V. (2014) Hemodialysis‐Specific Factors Associated with Salivary Flow Rates. Artificial Organs, 39, 181-186. [Google Scholar] [CrossRef] [PubMed]
[52] 吕洋. 不同频次冰水喷雾干预缓解ICU患者口渴的效果观察[D]: [硕士学位论文]. 荆州: 长江大学, 2022.
[53] Mina, R.J.L., Lerma, M.B., Litan, P.L.B., Milano, A.A.L., Mojica, A.D.R., Malong‐Consolacion, C.P., et al. (2019) Fluid Distribution Timetable on Adherence to Fluid Restriction of Patients with End‐Stage Renal Disease Undergoing Haemodialysis: Single‐Blind, Randomized‐Controlled Pilot Study. Journal of Advanced Nursing, 75, 1328-1337. [Google Scholar] [CrossRef] [PubMed]
[54] López-Pintor, R.M., López-Pintor, L., González-Serrano, J., et al. (2020) Impact and Efficacy of Topical Dry Mouth Products in Haemodialysis Patients with Xerostomia: A Pilot Study. Oral Health and Preventive Dentistry, 18, 1039-1045.
[55] Yıldırım Keskin, A. and Taşci, S. (2021) The Effect of Acupressure Applied to Individuals Receiving Hemodialysis Treatment on Severity of Thirst and Quality of Life. Alternative Therapies in Health and Medicine, 27, 20-30.
[56] Asgharpour, M., Enayati, N., Rezaei Sadrabadi, M., Mohamadi Afrakati, M., Khavandegar, A., Mardi, P., et al. (2022) Effects of Descurainia Sophia on Oxidative Stress Markers and Thirst Alleviation in Hemodialysis Patients: A Randomized Double-Blinded Placebo-Controlled Cross-Over Clinical Trial. Evidence-Based Complementary and Alternative Medicine, 2022, Article ID: 2001441. [Google Scholar] [CrossRef] [PubMed]
[57] Chen, Y.Q., Wang, C.L., Chiu, A.H., Yeh, M. and Chiang, T. (2023) Chewing Gum May Alleviate Degree of Thirst in Patients on Hemodialysis. Medicina, 60, Article No. 2. [Google Scholar] [CrossRef] [PubMed]
[58] Ao, H., Liu, Y.Q., Qian, S.L., et al. (2024) Enhancing Oral Mucosal Barrier, Mitigating Microinflammation, and Addressing Malnutrition in Dialysis Patients: The Impact of Tangerine Peel Lemon Glycerin. Alternative Therapies in Health and Medicine, 30, 168-173.
[59] Pan, Y., Wu, X., Zhu, M., Zhang, T., Gao, L., Zhu, Y., et al. (2024) Clinical Significance and Correlation of Compliance to Thirst in Maintenance Hemodialysis Patients. Technology and Health Care, 32, 1733-1743. [Google Scholar] [CrossRef] [PubMed]