2型糖尿病对心血管发病机制的研究进展
Research Progress on the Effect of T2DM On Cardiovascular Diseases
DOI: 10.12677/jcpm.2026.52107, PDF,   
作者: 苏克敏, 孙 静, 杨 烁：济宁医学院临床医学院(附属医院)，山东 济宁；李艳英, 张 梅, 刘福朋*：济宁医学院附属医院，内分泌遗传代谢科，山东 济宁
关键词: 心血管疾病；2型糖尿病；发病机制；危险因素；Cardiovascular Disease； Type 2 Diabetes； Pathogenesis； Risk Factors
摘要: 心血管疾病(CVD)是2型糖尿病(T2DM)的严重的大血管并发症之一，T2DM与CVD风险增加密切相关，T2DM是CVD的重要独立危险因素，CVD是T2DM患者发病和死亡的主要原因。本文总结了目前对T2DM促进CVD发生和进展机制的理解，讨论了高血糖、胰岛素抵抗、血脂异常、炎症、氧化应激和内皮功能障碍等因素在T2DM患者的CVD发病机制中的复杂相互作用。了解这些机制对于制定更有效的治疗策略从而减轻T2DM患者的CVD负担至关重要。
Abstract: Cardiovascular disease (CVD) is one of the serious macrovascular complications of type 2 diabetes mellitus (T2DM), and T2DM is closely associated with an increased risk of CVD, which is an important independent risk factor for CVD, and CVD is the leading cause of morbidity and mortality in patients with T2DM. This article summarizes the current understanding of the mechanisms by which T2DM promotes the development and progression of CVD, and discusses the complex interactions of factors such as hyperglycemia, insulin resistance, dyslipidemia, inflammation, oxidative stress, and endothelial dysfunction in the pathogenesis of CVD in patients with T2DM. Understanding these mechanisms is essential to develop more effective prevention and treatment strategies to reduce the burden of CVD in patients with T2DM.
文章引用：苏克敏, 孙静, 杨烁, 李艳英, 张梅, 刘福朋. 2型糖尿病对心血管发病机制的研究进展[J]. 临床个性化医学, 2026, 5(2): 107-113. https://doi.org/10.12677/jcpm.2026.52107

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