血管性痴呆发病机制中炎症因子与血脂异常的关联及相互作用研究进展

Research Progress on the Association and Interaction between Inflammatory Factors and Dyslipidemia in the Pathogenesis of Vascular Dementia

摘要: 我国是人口老龄化大国，而血管性痴呆(Vascular Dementia, VaD)是第二最常见类型的痴呆，且是痴呆患者中住院率最高的类型，引起严重的医疗及社会负担，已成为目前公认的健康挑战和医疗研究热点。但其发病机制复杂，危险因素众多且互相影响，因此对VaD早期识别提出了巨大的挑战。近年来，随着国内外对VaD相关研究的不断深入，我们也对VaD的发病及进展有了更清晰的认识。其中炎症与脂代谢紊乱是VaD发病机制中的关键因素，本综述将深入探讨炎症因子、血脂与血管性痴呆之间的复杂关系，旨在为理解VaD的病理机制和寻找潜在治疗靶点提供全面的视角。

Abstract: As a country with a large aging population, China faces significant healthcare challenges related to dementia. Vascular dementia (VaD) represents the second most common type of dementia and accounts for the highest hospitalization rate among dementia patients, imposing substantial medical and social burdens. It has become a widely recognized health challenge and a hot topic in medical research. However, the pathogenesis of VaD is complex, involving numerous interacting risk factors, which poses significant challenges for early identification. In recent years, with the deepening of domestic and international research on VaD, our understanding of its onset and progression has become clearer. Inflammation and lipid metabolism disorders are critical factors in the pathogenesis of VaD. This review explores the complex relationships between inflammatory factors, blood lipids, and vascular dementia, aiming to provide a comprehensive perspective for understanding the pathological mechanisms of VaD and identifying potential therapeutic targets.