子宫内膜异位症中干细胞与免疫炎症机制的 研究进展
Research Advances in Stem Cell-Mediated Immune and Inflammatory Mechanisms in Endometriosis
摘要: 子宫内膜异位症(EMT)是一种慢性激素依赖性炎性疾病，作为常见妇科疾病之一，对患者身心健康与生活质量均产生显著负面影响，且其发病机制至今尚不明确，导致其早诊早治困难，多数病情进展，进而造成不孕甚至癌变。近来，炎症免疫紊乱、子宫内膜细胞异位黏附及细胞异常侵袭增殖等被认为是内异症核心病理环节，干细胞学说及免疫炎症学说已成为EMT发病机制的研究热点，相关炎症通路关键因子及干细胞表面标志物为EMT的发病和诊疗提供了重要参考。本文基于干细胞学说及免疫炎症学说在EMT发病中的作用进行综述，以期为该疾病的发病提供新思路。
Abstract: Endometriosis (EMT) is a chronic hormone-dependent inflammatory disease. As one of the common gynecological conditions, it significantly impacts patients’ physical and mental health as well as their quality of life. Its pathogenesis remains unclear, hindering early diagnosis and treatment. Consequently, most cases progress, leading to infertility or even malignant transformation. Recent research identifies inflammatory immune dysregulation, ectopic adhesion of endometrial cells, and abnormal cellular invasion and proliferation as core pathological mechanisms. The stem cell theory and immune-inflammatory theory have emerged as key research focuses in elucidating EMT pathogenesis. Key factors in related inflammatory pathways and stem cell surface markers provide crucial insights for understanding the disease’s development and guiding its diagnosis and treatment. This review examines the roles of stem cell theory and immune-inflammatory theory in endometriosis pathogenesis, aiming to offer novel insights into the disease’s development.
文章引用：肖婷, 马瑛. 子宫内膜异位症中干细胞与免疫炎症机制的 研究进展[J]. 临床医学进展, 2026, 16(4): 146-155. https://doi.org/10.12677/acm.2026.1641235

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