深度学习在宫颈癌诊疗中的研究进展
Research Progress of Deep Learning in the Diagnosis and Treatment of Cervical Cancer
DOI: 10.12677/acm.2026.1641264, PDF,    科研立项经费支持
作者: 王 倩:内蒙古民族大学第二临床医学院,内蒙古 呼伦贝尔;王 斌*:内蒙古林业总医院医学影像中心,内蒙古 呼伦贝尔
关键词: 深度学习宫颈癌图像分析预后预测放射治疗规划Deep Learning Cervical Cancer Image Analysis Prognosis Prediction Radiotherapy Planning
摘要: 宫颈癌是全球女性健康的主要威胁之一,其早期诊断和精准治疗是改善预后的关键。近年来,深度学习技术凭借其强大的特征提取与模式识别能力在宫颈癌诊疗的多个关键环节展现出重要价值。本文综述了深度学习在宫颈癌筛查、病理诊断、影像分析、治疗规划及预后预测等方面的研究进展,重点分析了卷积神经网络、Transformer及其混合模型在细胞学、组织病理学及多模态医学影像中的关键应用,涵盖了从弱监督学习到多模态融合等多种技术策略。同时,本文也探讨了当前模型面临的数据异质性、临床可解释性及前瞻性验证不足等核心挑战,并对未来发展方向进行了展望,通过算法优化与临床需求的深度融合,深度学习正持续推动宫颈癌诊疗向自动化、个性化和精准化迈进。
Abstract: Cervical cancer is one of the major threats to women’s health worldwide, and its early diagnosis and precise treatment are key to improving prognosis. In recent years, deep learning technology has demonstrated significant value in multiple key aspects of cervical cancer diagnosis and treatment due to its powerful feature extraction and pattern recognition capabilities. This article reviews the research progress of deep learning in cervical cancer screening, pathological diagnosis, image analysis, treatment planning, and prognosis prediction, with a focus on analyzing the key applications of Convolutional Neural Networks (CNN), Transformer, and their hybrid models in cytology, histopathology, and multimodal medical imaging, covering various technical strategies from weakly supervised learning to multimodal fusion. At the same time, this article also discusses the core challenges currently faced by models, such as data heterogeneity, clinical interpretability, and insufficient prospective validation, and looks forward to future development directions. Through the deep integration of algorithm optimization and clinical needs, deep learning is continuously advancing the diagnosis and treatment of cervical cancer towards automation, individualization, and precision.
文章引用:王倩, 王斌. 深度学习在宫颈癌诊疗中的研究进展[J]. 临床医学进展, 2026, 16(4): 420-428. https://doi.org/10.12677/acm.2026.1641264

参考文献

[1] Yadav, P., Gupta, A., Parveen, A. and Kumar, A. (2022) Advancement in Deep Learning Methods for Diagnosis and Prognosis of Cervical Cancer. Current Genomics, 23, 234-245. [Google Scholar] [CrossRef] [PubMed]
[2] Desai, K.T., Befano, B., Xue, Z., Kelly, H., Campos, N.G., Egemen, D., et al. (2021) The Development of “Automated Visual Evaluation” for Cervical Cancer Screening: The Promise and Challenges in Adapting Deep‐Learning for Clinical Testing. International Journal of Cancer, 150, 741-752. [Google Scholar] [CrossRef] [PubMed]
[3] Debelee, T.G., Kebede, S.R., Schwenker, F. and Shewarega, Z.M. (2020) Deep Learning in Selected Cancers’ Image Analysis—A Survey. Journal of Imaging, 6, Article 121. [Google Scholar] [CrossRef] [PubMed]
[4] Li, X., Du, M., Zuo, S., Zhou, M., Peng, Q., Chen, Z., et al. (2023) Deep Convolutional Neural Networks Using an Active Learning Strategy for Cervical Cancer Screening and Diagnosis. Frontiers in Bioinformatics, 3, Article 1101667. [Google Scholar] [CrossRef] [PubMed]
[5] Sompawong, N., Mopan, J., Pooprasert, P., Himakhun, W., Suwannarurk, K., Ngamvirojcharoen, J., et al. (2019) Automated Pap Smear Cervical Cancer Screening Using Deep Learning. 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Berlin, 23-27 July 2019, 7044-7048. [Google Scholar] [CrossRef] [PubMed]
[6] Wentzensen, N., Lahrmann, B., Clarke, M.A., Kinney, W., Tokugawa, D., Poitras, N., et al. (2020) Accuracy and Efficiency of Deep-Learning-Based Automation of Dual Stain Cytology in Cervical Cancer Screening. JNCI: Journal of the National Cancer Institute, 113, 72-79. [Google Scholar] [CrossRef] [PubMed]
[7] Himabindu, D.D., Lydia, E.L., Rajesh, M.V., Ahmed, M.A. and Ishak, M.K. (2025) Leveraging Swin Transformer with Ensemble of Deep Learning Model for Cervical Cancer Screening Using Colposcopy Images. Scientific Reports, 15, Article No. 7900. [Google Scholar] [CrossRef] [PubMed]
[8] Yu, Y., Ma, J., Zhao, W., Li, Z. and Ding, S. (2021) MSCI: A Multistate Dataset for Colposcopy Image Classification of Cervical Cancer Screening. International Journal of Medical Informatics, 146, Article ID: 104352. [Google Scholar] [CrossRef] [PubMed]
[9] Kang, Z., Liu, J., Ma, C., Chen, C., Lv, X. and Chen, C. (2023) Early Screening of Cervical Cancer Based on Tissue Raman Spectroscopy Combined with Deep Learning Algorithms. Photodiagnosis and Photodynamic Therapy, 42, Article ID: 103557. [Google Scholar] [CrossRef] [PubMed]
[10] Zabihollahy, F., Viswanathan, A.N., Schmidt, E.J. and Lee, J. (2022) Fully Automated Segmentation of Clinical Target Volume in Cervical Cancer from Magnetic Resonance Imaging with Convolutional Neural Network. Journal of Applied Clinical Medical Physics, 23, e13725. [Google Scholar] [CrossRef] [PubMed]
[11] Liu, Z., Liu, X., Guan, H., Zhen, H., Sun, Y., Chen, Q., et al. (2020) Development and Validation of a Deep Learning Algorithm for Auto-Delineation of Clinical Target Volume and Organs at Risk in Cervical Cancer Radiotherapy. Radiotherapy and Oncology, 153, 172-179. [Google Scholar] [CrossRef] [PubMed]
[12] Gautam, S., Osman, A.F.I., Richeson, D., Gholami, S., Manandhar, B., Alam, S., et al. (2024) Attention 3D UNET for Dose Distribution Prediction of High‐Dose‐Rate Brachytherapy of Cervical Cancer: Intracavitary Applicators. Journal of Applied Clinical Medical Physics, 26, e14568. [Google Scholar] [CrossRef] [PubMed]
[13] Yang, B., Liu, Y., Chen, Z., Wang, Z., Zhou, Q. and Qiu, J. (2022) Tissues Margin-Based Analytical Anisotropic Algorithm Boosting Method via Deep Learning Attention Mechanism with Cervical Cancer. International Journal of Computer Assisted Radiology and Surgery, 18, 953-959. [Google Scholar] [CrossRef] [PubMed]
[14] Zhang, K., Sun, K., Zhang, C., Ren, K., Li, C., Shen, L., et al. (2023) Using Deep Learning to Predict Survival Outcome in Non-Surgical Cervical Cancer Patients Based on Pathological Images. Journal of Cancer Research and Clinical Oncology, 149, 6075-6083. [Google Scholar] [CrossRef] [PubMed]
[15] Du, T., Li, C., Grzegozek, M., Huang, X., Rahaman, M., Wang, X., et al. (2025) PET/CT Radiomics for Non-Invasive Prediction of Immunotherapy Efficacy in Cervical Cancer. Journal of X-Ray Science and Technology, 33, 1081-1092. [Google Scholar] [CrossRef
[16] Zhang, D., Zhao, L., Guo, B., Guo, A., Ding, J., Tong, D., et al. (2025) Integrated Machine Learning Algorithms-Enhanced Predication for Cervical Cancer from Mass Spectrometry-Based Proteomics Data. Bioengineering, 12, Article 269. [Google Scholar] [CrossRef] [PubMed]
[17] Chauhan, N.K., Singh, K., Kumar, A. and Kolambakar, S.B. (2023) HDFCN: A Robust Hybrid Deep Network Based on Feature Concatenation for Cervical Cancer Diagnosis on WSI Pap Smear Slides. BioMed Research International, 2023, Article ID: 4214817. [Google Scholar] [CrossRef] [PubMed]
[18] Kanavati, F., Hirose, N., Ishii, T., Fukuda, A., Ichihara, S. and Tsuneki, M. (2022) A Deep Learning Model for Cervical Cancer Screening on Liquid-Based Cytology Specimens in Whole Slide Images. Cancers, 14, Article 1159. [Google Scholar] [CrossRef] [PubMed]
[19] 李雪, 石中月, 杨志明, 等. 人工智能辅助分析在宫颈液基薄层细胞学检查中的应用价值[J]. 首都医科大学学报, 2020, 41(3): 360-363.
[20] Alsalatie, M., Alquran, H., Mustafa, W.A., Zyout, A., Alqudah, A.M., Kaifi, R., et al. (2023) A New Weighted Deep Learning Feature Using Particle Swarm and Ant Lion Optimization for Cervical Cancer Diagnosis on Pap Smear Images. Diagnostics, 13, Article 2762. [Google Scholar] [CrossRef] [PubMed]
[21] Alquran, H., Alsalatie, M., Mustafa, W.A., Abdi, R.A. and Ismail, A.R. (2022) Cervical Net: A Novel Cervical Cancer Classification Using Feature Fusion. Bioengineering, 9, Article 578. [Google Scholar] [CrossRef] [PubMed]
[22] 武爱媛, 热米拉∙热扎克, 乔友林. 人工智能在宫颈病变诊断及治疗中的应用进展与挑战[J]. 中国全科医学, 2022, 25(18): 2215-2222, 2230.
[23] Elakkiya, R., Subramaniyaswamy, V., Vijayakumar, V. and Mahanti, A. (2022) Cervical Cancer Diagnostics Healthcare System Using Hybrid Object Detection Adversarial Networks. IEEE Journal of Biomedical and Health Informatics, 26, 1464-1471. [Google Scholar] [CrossRef] [PubMed]
[24] Skerrett, E., Miao, Z., Asiedu, M.N., Richards, M., Crouch, B., Sapiro, G., et al. (2022) Multicontrast Pocket Colposcopy Cervical Cancer Diagnostic Algorithm for Referral Populations. BME Frontiers, 2022, Article ID: 9823184. [Google Scholar] [CrossRef] [PubMed]
[25] Hamdi, M., Senan, E.M., Awaji, B., Olayah, F., Jadhav, M.E. and Alalayah, K.M. (2023) Analysis of WSI Images by Hybrid Systems with Fusion Features for Early Diagnosis of Cervical Cancer. Diagnostics, 13, Article 2538. [Google Scholar] [CrossRef] [PubMed]
[26] Song, J., Im, S., Lee, S.H. and Jang, H. (2022) Deep Learning-Based Classification of Uterine Cervical and Endometrial Cancer Subtypes from Whole-Slide Histopathology Images. Diagnostics, 12, Article 2623. [Google Scholar] [CrossRef] [PubMed]
[27] Zhao, M., Ling, M., Wang, Z., Shi, J., Kan, H., An, H., et al. (2022) Whole Slide Image Multi-Classification of Cervical Epithelial Lesions Based on Unsupervised Pre-Training. 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Glasgow, 11-15 July 2022, 594-598. [Google Scholar] [CrossRef] [PubMed]
[28] Govindaraj, P., Natarajan, S., Sampath, P., Suresh, A.T. and Amirtharajan, R. (2025) A Hybrid Compound Scaling Hypergraph Neural Network for Robust Cervical Cancer Subtype Classification Using Whole Slide Cytology Images. Scientific Reports, 15, Article No. 22201. [Google Scholar] [CrossRef] [PubMed]
[29] Goto, M., Futamura, Y., Makishima, H., Saito, T., Sakamoto, N., Iijima, T., et al. (2025) Development of a Deep Learning-Based Model to Evaluate Changes during Radiotherapy Using Cervical Cancer Digital Pathology. Journal of Radiation Research, 66, 144-156. [Google Scholar] [CrossRef] [PubMed]
[30] 中国病理医师协会数字病理与人工智能病理学组, 中华医学会病理学分会数字病理与人工智能工作委员会, 中华医学会病理学分会细胞病理学组. 宫颈液基细胞学的数字病理图像采集与图像质量控制中国专家共识[J]. 中华病理学杂志, 2021, 50(4): 319-322.
[31] Chauhan, N.K., Singh, K., Kumar, A., Mishra, A., Gupta, S.K., Mahajan, S., et al. (2025) A Hybrid Learning Network with Progressive Resizing and PCA for Diagnosis of Cervical Cancer on WSI Slides. Scientific Reports, 15, Article No. 12801. [Google Scholar] [CrossRef] [PubMed]
[32] 赵延玉, 赵晓永, 王磊, 等. 可解释人工智能研究综述[J]. 计算机工程与应用, 2023, 59(14): 1-14.
[33] Kurita, Y., Meguro, S., Tsuyama, N., Kosugi, I., Enomoto, Y., Kawasaki, H., et al. (2023) Accurate Deep Learning Model Using Semi-Supervised Learning and Noisy Student for Cervical Cancer Screening in Low Magnification Images. PLOS ONE, 18, e0285996. [Google Scholar] [CrossRef] [PubMed]
[34] Ming, Y., Dong, X., Zhao, J., Chen, Z., Wang, H. and Wu, N. (2022) Deep Learning-Based Multimodal Image Analysis for Cervical Cancer Detection. Methods, 205, 46-52. [Google Scholar] [CrossRef] [PubMed]
[35] Zhang, Z., Zhang, C., Xiao, L. and Zhang, S. (2022) Diagnosis of Early Cervical Cancer with a Multimodal Magnetic Resonance Image under the Artificial Intelligence Algorithm. Contrast Media & Molecular Imaging, 2022, Article ID: 6495309. [Google Scholar] [CrossRef] [PubMed]
[36] Fan, Y., Ma, H., Fu, Y., Liang, X., Yu, H. and Liu, Y. (2022) Colposcopic Multimodal Fusion for the Classification of Cervical Lesions. Physics in Medicine & Biology, 67, Article ID: 135003. [Google Scholar] [CrossRef] [PubMed]
[37] 贾利叶, 任雪婷, 赵涓涓, 等. 人工智能在肺癌影像基因组学方面的研究与进展[J]. 太原理工大学学报, 2022, 53(4): 571-587.
[38] Wu, K., Chen, S., Hsieh, T., Yen, K., Chang, C., Kuo, Y., et al. (2023) Early Prediction of Distant Metastasis in Patients with Uterine Cervical Cancer Treated with Definitive Chemoradiotherapy by Deep Learning Using Pretreatment [18F]fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. Nuclear Medicine Communications, 45, 196-202. [Google Scholar] [CrossRef] [PubMed]
[39] Fu, Q., Chen, X., Liu, Y., Zhang, J., Xu, Y., Yang, X., et al. (2024) Improvement of Accumulated Dose Distribution in Combined Cervical Cancer Radiotherapy with Deep Learning-Based Dose Prediction. Frontiers in Oncology, 14, Article 1407016. [Google Scholar] [CrossRef] [PubMed]
[40] Guo, L., Zhang, S., Chen, H., Li, Y., Liu, Y., Liu, W., et al. (2025) Application of Artificial Intelligence in Assisting Treatment of Gynecologic Tumors: A Systematic Review. Visual Computing for Industry, Biomedicine, and Art, 8, Article No. 23. [Google Scholar] [CrossRef
[41] Cui, J., Xiao, J., Hou, Y., Wu, X., Zhou, J., Peng, X., et al. (2023) Unsupervised Domain Adaptive Dose Prediction via Cross-Attention Transformer and Target-Specific Knowledge Preservation. International Journal of Neural Systems, 33, Article ID: 23500570. [Google Scholar] [CrossRef] [PubMed]
[42] Pfohl, U., Pflaume, A., Regenbrecht, M., Finkler, S., Graf Adelmann, Q., Reinhard, C., et al. (2021) Precision Oncology Beyond Genomics: The Future Is Here—It Is Just Not Evenly Distributed. Cells, 10, Article 928. [Google Scholar] [CrossRef] [PubMed]
[43] Nguyen, R. and Vafaee, F. (2025) Multi-Omics Prognostic Marker Discovery and Survival Modelling: A Case Study on Multi-Cancer Survival Analysis of Women’s Specific Tumours. Scientific Reports, 15, Article No. 36706. [Google Scholar] [CrossRef
[44] Montero-Macías, R., Veyer, D., Bruneau, T., Robillard, N., Le Frère-Belda, M., Rigolet, P., et al. (2023) TRANSLACOL Project: Nodal Human Papillomavirus Tumoral DNA Detection by ddPCR for Survival Prediction in Early Cervical Cancer Patients without Pelvic Lymph Node Invasion. Journal of Clinical Virology, 161, Article ID: 105418. [Google Scholar] [CrossRef] [PubMed]
[45] Ray-Coquard, I., Kaminsky-Forrett, M., Ohkuma, R., de Montfort, A., Joly, F., Treilleux, I., et al. (2026) Neoadjuvant Immune Checkpoint Blockade before Chemoradiation for Cervical Squamous Carcinoma (GINECO Window-of-Opportunity COLIBRI Study): A Phase II Trial. Nature Communications, 17, Article No. 922. [Google Scholar] [CrossRef
[46] Yun, H., Han, G.H., Wee, D.J., Chay, D., Chung, J., Kim, J., et al. (2025) Loss of E-Cadherin Activates EGFR-MEK/ERK Signaling, Promoting Cervical Cancer Progression. Cancer GenomicsProteomics, 22, 271-284. [Google Scholar] [CrossRef] [PubMed]
[47] Halle, M.K., Hodneland, E., Wagner-Larsen, K.S., Lura, N.G., Fasmer, K.E., Berg, H.F., et al. (2024) Radiomic Profiles Improve Prognostication and Reveal Targets for Therapy in Cervical Cancer. Scientific Reports, 14, Article No. 11339. [Google Scholar] [CrossRef] [PubMed]
[48] Luciano, N., Orlandella, F.M., Braile, M., Cavaliere, C., Aiello, M., Franzese, M., et al. (2024) Association of Radiomic Features with Genomic Signatures in Thyroid Cancer: A Systematic Review. Journal of Translational Medicine, 22, Article No. 1088. [Google Scholar] [CrossRef] [PubMed]
[49] Saini, S.K., Sharma, D.N., Chauhan, S., Srivastava, S., Gopishankar, N. and Subramani, V. (2025) Precision Prediction of Cervical Cancer Outcomes: A Machine Learning Approach to Recurrence and Survival Analysis. Journal of Cancer Research and Therapeutics, 21, 538-546. [Google Scholar] [CrossRef] [PubMed]
[50] 唐玲玲, 李力. 大数据与人工智能在妇科恶性肿瘤中的研究与应用[J]. 中国实用妇科与产科杂志, 2019, 35(6): 720-723.