组织蛋白酶在早发性卵巢功能不全中的作用及研究进展
The Role of Cathepsins in Premature Ovarian Insufficiency: Mechanisms and Research Advances
DOI: 10.12677/acm.2026.1641273, PDF,   
作者: 马莹莹, 勾露玉, 王 玉：延安大学医学院，陕西 延安；张媛媛：延安大学附属医院妇产科生殖医学中心，陕西 延安
关键词: 组织蛋白酶；早发性卵巢功能不全；POI；Cathepsins； Premature Ovarian Insufficiency； POI
摘要: 早发性卵巢功能不全(POI)是指女性40岁以前发生卵巢功能减退的生殖内分泌疾病之一，其严重影响女性生育力及身心健康，目前病理机制尚未阐明。组织蛋白酶是一类主要存在于溶酶体中的蛋白酶，参与抗原呈递、细胞外基质重塑等多种生理病理过程。近年研究发现，组织蛋白酶在卵巢功能减退的发生发展中发挥重要作用，可通过调控颗粒细胞凋亡、卵泡闭锁、氧化应激及炎症反应等途径影响卵巢功能，但其因果关系及临床转化价值仍需验证。本文就组织蛋白酶在POI中的作用及研究进展进行综述。
Abstract: Premature ovarian insufficiency (POI) is a reproductive endocrine disorder characterized by the decline of ovarian function occurring in women before the age of 40 years. It severely impairs female fertility and physical-mental health, while its pathological mechanisms remain to be fully elucidated. Cathepsins are a class of proteases predominantly localized in lysosomes, involved in various physiological and pathological processes including antigen presentation and extracellular matrix remodeling. Recent studies have revealed that cathepsins play pivotal roles in the pathogenesis of ovarian function decline, affecting ovarian function through modulating granulosa cell apoptosis, follicular atresia, oxidative stress, and inflammatory responses. However, their causal relationships and clinical translational value remain to be validated. This review summarizes the roles of cathepsins in premature ovarian insufficiency (POI) and the recent research progress in this field.
文章引用：马莹莹, 勾露玉, 王玉, 张媛媛. 组织蛋白酶在早发性卵巢功能不全中的作用及研究进展[J]. 临床医学进展, 2026, 16(4): 497-504. https://doi.org/10.12677/acm.2026.1641273

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