血清PCT、CRP和婴幼儿社区获得性肺炎严重程度的相关性分析

Analysis of the Correlation between Serum Procalcitonin (PCT), C-Reactive Protein (CRP) and the Severity of Community-Acquired Pneumonia in Infants and Young Children

摘要: 目的：探究降钙素原(procalcitonin, PCT)、C-反应蛋白(C-reactive protein, CRP)指标与婴幼儿社区获得性肺炎严重程度的相关性。方法：选取2023.01~2024.12期间到我院就诊的社区获得性肺炎患儿96例作为观察对象，其按照标准分为普通社区获得性肺炎患儿74例，设为普通组，将重症社区获得性肺炎患儿22例设为重症组，对两组患儿实施血清PCT、CRP检测，并对检测结果进行多因素Logistic回归分析。结果：重症组患儿的血清PCT与CRP指标水平均相对高于普通组，差异有统计学意义(P < 0.05)；经多因素Logistic回归分析，血清PCT (OR = 3.323, 95%CI = 1.403~7.873, P = 0.006)与CRP指标(OR = 1.030, 95%CI = 1.003~1.059, P = 0.032)是影响社区获得性肺炎病情严重程度的独立危险因素(P < 0.05)。结论：婴幼儿社区获得性肺炎的严重程度与血清PCT、CRP指标水平呈正相关的关系，当检测婴幼儿血清PCT、CRP指标水平升高，提示病情有加重趋势，对疾病早期预测与制定治疗方案具有重要价值。

Abstract: Objective: To explore the correlation between serum procalcitonin (PCT), C-reactive protein (CRP) levels and the severity of community-acquired pneumonia in infants and young children. Methods: A total of 96 children with community-acquired pneumonia admitted to our hospital from January 2023 to December 2024 were selected as study subjects. According to the standard criteria, they were divided into the general group (74 children with non-severe community-acquired pneumonia) and the severe group (22 children with severe community-acquired pneumonia). Serum PCT and CRP tests were performed for both groups, and multivariate logistic regression analysis was conducted on the test results. Results: The average serum levels of PCT and CRP in the severe group were significantly higher than those in the general group, with a statistically significant difference (P < 0.05). Multivariate logistic regression analysis showed that serum PCT (OR = 3.323, 95%CI = 1.403~7.873, P = 0.006) and CRP (OR = 1.030, 95%CI = 1.003~1.059, P = 0.032) were independent risk factors affecting the severity of community-acquired pneumonia (P < 0.05). Conclusion: The severity of community-acquired pneumonia in infants and young children is positively correlated with serum PCT and CRP levels. Elevated serum PCT and CRP levels in infants and young children indicate an aggravating trend of the disease, which is of important value for early prediction of the disease and formulation of treatment regimens.