六味地黄丸治疗肾阴虚型绝经后骨质疏松症的机制研究进展

Research Progress on the Mechanism of Liuwei Dihuang Pill in Treating Postmenopausal Osteoporosis of Kidney Yin Deficiency Type

摘要: 绝经后骨质疏松症是一种与衰老有关的骨代谢疾病，主要发生于绝经后妇女，由于雌激素缺乏导致骨量减少及骨组织结构变化，使骨脆性增多，易于骨折，严重地影响老年女性的身体健康和生活质量，甚至缩短寿命。而在POMP早期症状不明显，缺乏特异性临床表现，直到轻微的创伤诱发骨折引起疼痛、骨骼变形、出现合并症才会引起重视，所以早期的PMOP预防十分关键。而传统中药复方在预防和治疗PMOP方面有着悠久的历史与渊源，抗骨质疏松中药复方与单一药物相比具有明显的优势。六味地黄丸作为经典补肾阴方剂，临床运用广泛，疗效确切。通过检索近年来关于六味地黄丸治疗PMOP相关文献，从六味地黄丸对骨髓间充质干细胞(bone marrow mesenchymal stem cells, BMSCs)、成骨细胞(osteoblasts, OB)的作用及干预骨质疏松症相关信号通路的进展，探讨六味地黄丸对PMOP的潜在治疗机制。

Abstract: Postmenopausal osteoporosis (PMOP) is a bone metabolic disorder associated with aging, primarily occurring in postmenopausal women. Due to estrogen deficiency, it leads to a reduction in bone mass and changes in bone tissue structure, resulting in increased bone fragility and susceptibility to fractures. This condition severely affects the physical health and quality of life of elderly women and may even shorten their lifespan. In the early stages of PMOP, symptoms are often subtle and lack specific clinical manifestations. It is not until minor trauma triggers fractures, causing pain, skeletal deformities, and complications, that the condition receives attention. Therefore, early prevention of PMOP is crucial. Traditional Chinese medicine (TCM) compounds have a long history and profound background in preventing and treating PMOP, offering significant advantages over single-drug therapies. Liuwei Dihuang Pills, a classic formula for nourishing kidney yin, are widely used clinically with proven efficacy. By reviewing recent literature on the treatment of PMOP with Liuwei Dihuang Pills, this paper explores the potential therapeutic mechanisms of Liuwei Dihuang Pills in PMOP by examining their effects on bone marrow mesenchymal stem cells (BMSCs), osteoblasts (OBs), and their intervention in signaling pathways related to osteoporosis.