卵圆孔未闭合并房间隔膨出瘤的介入治疗 研究进展
Research Progress on Interventional Treatment of Patent Foramen Ovale Combined with Atrial Septal Aneurysm
DOI: 10.12677/acm.2026.1641294, PDF,   
作者: 柳浩南, 姜小飞*：暨南大学珠海临床医学院(珠海市人民医院，北京理工大学附属医院)，广东 珠海
关键词: 介入治疗；卵圆孔未闭；房间隔膨出瘤；Interventional Therapy； Patent Foramen Ovale； Atrial Septal Aneurysm
摘要: 卵圆孔未闭(Patent foramen ovale, PFO)是一种在人群中患病率较高的先天性心脏病，经皮介入封堵治疗在既往研究中已被明确对于PFO相关脑卒中具有预防意义。房间隔膨出瘤(Atrial septal aneurysm, ASA)表现为房间隔处向左心房或右心房，或左右两侧心房膨出的囊袋样畸形结构，是一种少见的先天性房间隔发育异常疾病。PFO与隐源性卒中的发生具有显著相关性，当PFO合并ASA时，可增加再发隐源性卒中的风险。PFO合并ASA的介入治疗常因膨出的瘤体结构导致封堵器容易发生移位，导致残余分流。因此对于此类患者而言，经皮介入治疗仍存在诸多挑战，其有效性及安全性仍需进一步证实。现就PFO与ASA的解剖学特点，及二者合并状态下的介入治疗研究现状进行综述。
Abstract: Patent foramen ovale (PFO) is a congenital heart defect with a relatively high prevalence in the population. Percutaneous interventional closure has been clearly demonstrated in previous studies to have preventive significance for PFO-related stroke. Atrial septal aneurysm (ASA) manifests as a sac-like malformation bulging into the left atrium, right atrium, or both atria at the atrial septum, representing a rare congenital developmental anomaly of the atrial septum. PFO is significantly associated with cryptogenic stroke, and when combined with ASA, it may increase the risk of recurrent cryptogenic stroke. Interventional treatment for PFO combined with ASA often faces challenges due to the bulging aneurysm structure, which can lead to device displacement and residual shunting. Therefore, percutaneous interventional therapy still presents many challenges for such patients, and its efficacy and safety require further validation. This article reviews the anatomical characteristics of PFO and ASA, as well as the current research status of interventional therapy for their combined condition.
文章引用：柳浩南, 姜小飞. 卵圆孔未闭合并房间隔膨出瘤的介入治疗 研究进展[J]. 临床医学进展, 2026, 16(4): 675-681. https://doi.org/10.12677/acm.2026.1641294

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