Kisspeptin-GnRH通路在多囊卵巢综合征治疗中的研究进展
Research Progress on the Kisspeptin-GnRH Pathway in the Treatment of Polycystic Ovary Syndrome
摘要: 多囊卵巢综合征(PCOS)患者的高水平Kisspeptin驱动促性腺激素释放激素(GnRH)脉冲频率增加，引起黄体生成素/卵泡雌激素(LH/FSH)异常增高，导致患者出现卵巢多囊性改变、无排卵及高雄激素血症。在Kisspeptin-GnRH通路中Kisspeptin受体拮抗剂与激动剂，通过调节Kisspeptin水平影响GnRH脉冲频率以调控LH水平，改善患者的内分泌紊乱或模拟生理LH分泌安全诱导排卵；PCOS常用药物及中医药也能够下调Kisspeptin改善LH/FSH失衡，恢复卵巢功能；Kisspeptin-GnRH通路为PCOS的临床治疗提供新的思路。
Abstract: Elevated levels of Kisspeptin in patients with polycystic ovary syndrome (PCOS) drive an increased frequency of gonadotropin-releasing hormone (GnRH) pulses, leading to abnormal elevations in luteinizing hormone/follicle-stimulating hormone (LH/FSH). This results in polycystic ovarian morphology, anovulation, and hyperandrogenemia. Within the Kisspeptin-GnRH pathway, Kisspeptin receptor antagonists and agonists can regulate LH levels by modulating Kisspeptin activity to influence GnRH pulse frequency, thereby improving endocrine disturbances or safely inducing ovulation by mimicking physiological LH secretion. Conventional PCOS medications and traditional Chinese medicine can also downregulate Kisspeptin, ameliorate the LH/FSH imbalance, and restore ovarian function. The Kisspeptin-GnRH pathway offers novel insights for the clinical management of PCOS.
文章引用：陈建涛, 冯馨锐, 王婷, 赵江东, 周源, 路会侠. Kisspeptin-GnRH通路在多囊卵巢综合征治疗中的研究进展[J]. 临床医学进展, 2026, 16(4): 844-851. https://doi.org/10.12677/acm.2026.1641314

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