维持线粒体质量对预防心肌缺血再灌注损伤的作用及机制
The Role and Mechanism of Maintaining Mitochondrial Quality in Preventing Myocardial Ischemia-Reperfusion Injury
DOI: 10.12677/acm.2026.1641318, PDF,    科研立项经费支持
作者: 于 云, 刘振兵*：内蒙古医科大学鄂尔多斯临床医学院，内蒙古 鄂尔多斯
关键词: 心肌缺血再灌注损伤；线粒体生物发生；线粒体自噬；线粒体动力学；Myocardial Ischemia-Reperfusion Injury； Mitochondrial Biogenesis； Mitochondrial Autophagy； Mitochondrial Dynamics
摘要: 及时的再灌注治疗能够减少急性心肌梗死(AMI)患者的梗死面积，但心肌血流恢复会引起心肌缺血再灌注损伤(MIRI)，反而会加重心脏结构破坏，引起心肌细胞死亡，致使心肌梗死(MI)灶范围扩大，甚至引发心力衰竭(HF)。因此，除了快速心肌再灌注外，避免MIRI仍然是迫切需求。心肌细胞高度依赖线粒体的氧化代谢维持其正常功能。线粒体作为心肌细胞的能量代谢中心，其质量维持对心肌细胞正常功能至关重要。本文总结了维持线粒体质量对预防心肌缺血再灌注损伤的作用及机制。
Abstract: Timely reperfusion therapy can reduce the infarct size of patients with acute myocardial infarction (AMI), but the recovery of myocardial blood flow will lead to myocardial ischemia-reperfusion injury (MIRI), which will aggravate the destruction of heart structure, cause the death of myocardial cells, expand the scope of myocardial infarction (MI), and even lead to heart failure (HF). Therefore, in addition to rapid myocardial reperfusion, avoidance of MIRI remains an urgent need. Cardiomyocytes are highly dependent on the oxidative metabolism of mitochondria to maintain their normal function. As the energy metabolism center of cardiomyocytes, the quality maintenance of mitochondria is very important for the normal function of cardiomyocytes. This article summarizes the effect and mechanism of maintaining mitochondrial quality on preventing myocardial ischemia-reperfusion injury.
文章引用：于云, 刘振兵. 维持线粒体质量对预防心肌缺血再灌注损伤的作用及机制[J]. 临床医学进展, 2026, 16(4): 879-885. https://doi.org/10.12677/acm.2026.1641318

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