益气活血生肌方治疗糖尿病足研究 进展

Research Progress in Yiqi Huoxue Shengji Formula in the Treatment of Diabetic Foot

摘要: 糖尿病足是糖尿病最严重的慢性并发症之一，以下肢血管病变、神经病变及创面难愈为核心特征，具有高致残率、高死亡率及高医疗负担的特点，严重威胁患者生命质量。中医将其归属于“脱疽”范畴，认为气虚血瘀、脉络阻滞、肌肤失养是核心病机，益气活血生肌方凭借“扶正祛瘀、通络生新”的功效，在糖尿病足治疗中展现出独特优势。本文系统梳理近年来益气活血生肌方的临床应用现状，重点阐述其在糖尿病足中的临床疗效、作用机制及研究热点，从方剂配伍、临床干预、药理机制等方面进行综述，分析当前研究存在的不足，并对未来研究方向进行展望，为益气活血生肌方的临床推广及深入研究提供参考依据。

Abstract: Diabetic foot is one of the most severe chronic complications of diabetes mellitus, characterized primarily by lower extremity vascular lesions, neuropathy, and impaired wound healing. It is associated with high disability rates, high mortality, and a substantial healthcare burden, posing a serious threat to patients’ quality of life. In traditional Chinese medicine, diabetic foot falls under the category of “gangrene”, with the core pathogenesis attributed to qi deficiency, blood stasis, meridian obstruction, and malnutrition of the skin. The Yiqi Huoxue Shengji Formula has demonstrated unique advantages in diabetic foot treatment by “reinforcing healthy qi, dispelling stasis, unblocking collaterals, and promoting tissue regeneration”. This article systematically reviews the clinical applications of the Yiqi Huoxue Shengji Formula in recent years, focusing on its clinical efficacy, mechanisms of action, and research trends in diabetic foot management. It provides a comprehensive analysis from the perspectives of herbal formulation compatibility, clinical interventions, and pharmacological mechanisms, while also addressing current research limitations. Furthermore, it offers insights into future research directions, serving as a valuable reference for the clinical promotion and in-depth study of the Yiqi Huoxue Shengji Formula.