中性粒细胞与牙龈卟啉单胞菌相互作用的进展研究
Progress in the Study of Interactions between Neutrophils and Porphyromonas gingivalis
DOI: 10.12677/acm.2026.1641346, PDF,    科研立项经费支持
作者: 苏晓珂：重庆医科大学口腔医学院，重庆；李雨舟*, 杨 生*：重庆医科大学口腔医学院，重庆；口腔疾病研究重庆市重点实验室，重庆；重庆市高等教育口腔生物医学工程重点实验室，重庆
关键词: 中性粒细胞；牙龈卟啉单胞菌；牙周炎；中性粒细胞胞外陷阱；牙龈蛋白酶；Neutrophils； Porphyromonas gingivalis； Periodontitis； Neutrophil Extracellular Traps； Gingipains
摘要: 中性粒细胞是先天免疫系统的核心效应细胞，在口腔感染防御中发挥吞噬、脱颗粒及形成胞外陷阱(NETs)等关键作用。牙龈卟啉单胞菌(Porphyromonas gingivalis)作为牙周炎的关键病原体，通过脂多糖(LPS)、牙龈蛋白酶(gingipains)、牙龈卟啉单胞菌肽基精氨酸脱亚胺酶(PPAD)等毒力因子，可逃逸中性粒细胞杀伤并加剧慢性炎症。值得注意的是，两者的相互作用不仅局限于牙周组织破坏，还可能通过免疫调节参与类风湿性关节炎、阿尔茨海默病等全身性疾病的发生发展。然而，现有研究对二者互作的分子机制及其系统性影响尚未充分阐明。本文系统综述中性粒细胞与牙龈卟啉单胞菌的相互作用模式，旨在为牙周炎及相关全身性疾病的防治提供新视角。
Abstract: Neutrophils are core effector cells of the innate immune system, playing key roles in oral infection defense through phagocytosis, degranulation, and the formation of extracellular traps (NETs). Porphyromonas gingivalis, as a key pathogen in periodontitis, can evade neutrophil killing and exacerbate chronic inflammation via virulence factors, such as lipopolysaccharide (LPS), gingipains, and the Porphyromonas gingivalis peptidylarginine deiminase (PPAD). Notably, the interaction between the two is not confined to periodontal tissue destruction but may also participate in the pathogenesis of systemic diseases, such as rheumatoid arthritis and Alzheimer’s disease through immunomodulation. However, the molecular mechanisms of their interaction and its systemic implications remain insufficiently elucidated. This review systematically summarizes the modes of interaction between neutrophils and P. gingivalis, aiming to provide new insights into the prevention and treatment of periodontitis and related systemic diseases.
文章引用：苏晓珂, 李雨舟, 杨生. 中性粒细胞与牙龈卟啉单胞菌相互作用的进展研究[J]. 临床医学进展, 2026, 16(4): 1130-1138. https://doi.org/10.12677/acm.2026.1641346

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