TH17细胞和Treg细胞在梅毒血清固定发病机制中的作用
The Role of TH17 Cells and Treg Cells in the Pathogenesis of Serofast Syphilis
DOI: 10.12677/md.2026.162027, PDF,   
作者: 牛楚楚*, 仁 波*, 任士威：济宁医学院临床医学院，山东 济宁；郭 焕#：济宁医学院附属医院检验科，山东 济宁；卢 彬：济宁医学院附属医院皮肤科，山东 济宁
关键词: 梅毒血清固定；Th17/Treg细胞；细胞免疫失衡；细胞免疫抑制；Syphilis Serofast； TH17/Treg Cells； Cellular Immune Imbalance； Cellular Immunosuppression
摘要: 人们对梅毒的自然历史了解很多，但对梅毒血清固定的发病机制的了解不够深入，由于梅毒在中国的患病率不断上升，血清固定率也出现了较大的增长，然而梅毒血清固定的发生机制尚不明确，而且患者的临床预后往往存在多种不确定因素，因此血清固定已经成为梅毒的预防和控制，尤其是临床诊断和治疗所面临的疑难问题。目前有研究表明梅毒血清固定和多种因素有关，比如梅毒螺旋体的免疫原性，临床因素，体液免疫，细胞免疫和免疫失衡。特别地，细胞免疫中的Th17细胞的免疫作用以及它与Treg细胞失衡在梅毒血清固定的发病机制中扮演着重要角色。
Abstract: People have a lot of knowledge about the natural history of syphilis, but the understanding of the pathogenesis of syphilis serofast is not deep enough. Due to the rising prevalence of syphilis in China, the serofast rate has also increased greatly. However, the pathogenesis of syphilis serofast is not clear, and there are many uncertain factors in the clinical prognosis of patients. Therefore, serofast has become a difficult problem in the prevention and control of syphilis, especially in clinical diagnosis and treatment. At present, studies have shown that syphilis serofast is related to a variety of factors, such as the immunogenicity of Treponema pallidum, clinical factors, humoral immunity, cellular immunity and immune imbalance. In particular, the immune function of Th17 cells in cellular immunity and its imbalance with Treg cells play an important role in the pathogenesis of syphilis seroresistance. This article reviews the role of Th17 cells in the pathogenesis of serofast syphilis.
文章引用：牛楚楚, 仁波, 郭焕, 卢彬, 任士威. TH17细胞和Treg细胞在梅毒血清固定发病机制中的作用 [J]. 医学诊断, 2026, 16(2): 197-205. https://doi.org/10.12677/md.2026.162027

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