记忆提取抑制的认知与神经机制:行为与神经影像研究
Cognitive and Neural Mechanisms of Retrieval Suppression: Evidence from Behavioral and Neuroimaging Studies
摘要: 主动抑制不希望回忆的记忆提取被称为记忆提取抑制,通常通过Think/No-Think (TNT)范式进行研究。围绕抑制诱导性遗忘(Suppression-Induced Forgetting, SIF)的产生机制,目前主要存在抑制假说与干扰假说两种解释。本文综述了基于TNT范式的行为研究与神经影像证据。现有研究总体支持抑制假说,即记忆提取抑制依赖执行控制系统对目标记忆表征的主动抑制。神经影像学研究表明,该过程涉及前额叶控制网络对海马自上而下的调控,从而降低与记忆提取相关的海马体活动。未来研究应进一步探讨奖赏相关记忆中提取抑制的机制,以及抑制控制网络与不同记忆表征系统之间的神经协调作用。
Abstract: Memory retrieval suppression refers to the voluntary inhibition of unwanted memories from entering awareness, and it is commonly investigated using the Think/No-Think (TNT) paradigm. Two main theoretical accounts have been proposed to explain the mechanism underlying suppression-induced forgetting (SIF): the inhibition hypothesis and the interference hypothesis. This review summarizes behavioral and neuroimaging evidence from studies using the TNT paradigm. Overall, existing findings tend to support the inhibition hypothesis, suggesting that memory retrieval suppression relies on executive control processes that actively suppress target memory representations. Neuroimaging studies further indicate that this process involves top-down regulation from the prefrontal control network to the hippocampus, which reduces hippocampal activity associated with memory retrieval. Future research should further examine the mechanisms of retrieval suppression in reward-related memories and the neural coordination between inhibitory control networks and different memory systems.
文章引用:堵松玮 (2026). 记忆提取抑制的认知与神经机制:行为与神经影像研究. 心理学进展, 16(4), 52-62. https://doi.org/10.12677/ap.2026.164173

参考文献

[1] Anderson, M. (2003). Rethinking Interference Theory: Executive Control and the Mechanisms of Forgetting. Journal of Memory and Language, 49, 415-445.[CrossRef
[2] Anderson, M. C., & Green, C. (2001). Suppressing Unwanted Memories by Executive Control. Nature, 410, 366-369.[CrossRef] [PubMed]
[3] Anderson, M. C., & Hanslmayr, S. (2014). Neural Mechanisms of Motivated Forgetting. Trends in Cognitive Sciences, 18, 279-292.[CrossRef] [PubMed]
[4] Anderson, M. C., & Huddleston, E. (2012). Towards a Cognitive and Neurobiological Model of Motivated Forgetting. In R. F. Belli (Ed.), True and False Recovered Memories (pp. 53-120). Springer.[CrossRef] [PubMed]
[5] Anderson, M. C., & Hulbert, J. C. (2021). Active Forgetting: Adaptation of Memory by Prefrontal Control. Annual Review of Psychology, 72, 1-36.[CrossRef] [PubMed]
[6] Anderson, M. C., & Subbulakshmi, S. (2024). Amnesia in Healthy People via Hippocampal Inhibition: A New Forgetting Mechanism. Quarterly Journal of Experimental Psychology, 77, 1-13.[CrossRef] [PubMed]
[7] Anderson, M. C., Bunce, J. G., & Barbas, H. (2016). Prefrontal-Hippocampal Pathways Underlying Inhibitory Control over Memory. Neurobiology of Learning and Memory, 134, 145-161.[CrossRef] [PubMed]
[8] Anderson, M. C., Ochsner, K. N., Kuhl, B., Cooper, J., Robertson, E., Gabrieli, S. W. et al. (2004). Neural Systems Underlying the Suppression of Unwanted Memories. Science, 303, 232-235.[CrossRef] [PubMed]
[9] Anderson, M. C., Reinholz, J., Kuhl, B. A., & Mayr, U. (2011). Intentional Suppression of Unwanted Memories Grows More Difficult as We Age. Psychology and Aging, 26, 397-405.[CrossRef] [PubMed]
[10] Apšvalka, D., Ferreira, C. S., Schmitz, T. W., Rowe, J. B., & Anderson, M. C. (2022). Dynamic Targeting Enables Domain-General Inhibitory Control over Action and Thought by the Prefrontal Cortex. Nature Communications, 13, Article No. 274.[CrossRef] [PubMed]
[11] Bartholdy, S., O’Daly, O. G., Campbell, I. C., Banaschewski, T., Barker, G., Bokde, A. L. W. et al. (2019). Neural Correlates of Failed Inhibitory Control as an Early Marker of Disordered Eating in Adolescents. Biological Psychiatry, 85, 956-965.[CrossRef] [PubMed]
[12] Benoit, R. G., & Anderson, M. C. (2012). Opposing Mechanisms Support the Voluntary Forgetting of Unwanted Memories. Neuron, 76, 450-460.[CrossRef] [PubMed]
[13] Benoit, R. G., Davies, D. J., & Anderson, M. C. (2016). Reducing Future Fears by Suppressing the Brain Mechanisms Underlying Episodic Simulation. Proceedings of the National Academy of Sciences of the United States of America, 113, E8492-E8501.[CrossRef] [PubMed]
[14] Benoit, R. G., Hulbert, J. C., Huddleston, E., & Anderson, M. C. (2015). Adaptive Top–down Suppression of Hippocampal Activity and the Purging of Intrusive Memories from Consciousness. Journal of Cognitive Neuroscience, 27, 96-111.[CrossRef] [PubMed]
[15] Bergström, Z. M., de Fockert, J. W., & Richardson-Klavehn, A. (2009). ERP and Behavioural Evidence for Direct Suppression of Unwanted Memories. NeuroImage, 48, 726-737.[CrossRef] [PubMed]
[16] Bian, Z., Yang, R., Yang, X., Liu, Y., Gao, X., & Chen, H. (2021). Influence of Negative Mood on Restrained Eaters’ Memory Suppression of Food Cues: An Event-Related Potentials Study. Appetite, 164, Article ID: 105269.[CrossRef] [PubMed]
[17] Crone, E. A., & Dahl, R. E. (2012). Understanding Adolescence as a Period of Social-Affective Engagement and Goal Flexibility. Nature Reviews Neuroscience, 13, 636-650.[CrossRef] [PubMed]
[18] Cui, K., Zhao, J., Li, R., Gao, Y., & Gao, X. (2023). Higher Visceral Adipose Tissue Is Associated with Decreased Memory Suppression Ability on Food-Related Thoughts: A 1-Year Prospective ERP Study. Appetite, 191, Article ID: 107048.[CrossRef] [PubMed]
[19] Depue, B. E., Curran, T., & Banich, M. T. (2007). Prefrontal Regions Orchestrate Suppression of Emotional Memories via a Two-Phase Process. Science, 317, 215-219.[CrossRef] [PubMed]
[20] Engen, H. G., & Anderson, M. C. (2018). Memory Control: A Fundamental Mechanism of Emotion Regulation. Trends in Cognitive Sciences, 22, 982-995.[CrossRef] [PubMed]
[21] Fosco, W. D., Hawk, L. W., Colder, C. R., Meisel, S. N., & Lengua, L. J. (2019). The Development of Inhibitory Control in Adolescence and Prospective Relations with Delinquency. Journal of Adolescence, 76, 37-47.[CrossRef] [PubMed]
[22] Gagnepain, P., Henson, R. N., & Anderson, M. C. (2014). Suppressing Unwanted Memories Reduces Their Unconscious Influence via Targeted Cortical Inhibition. Proceedings of the National Academy of Sciences of the United States of America, 111, E1310-E1319.[CrossRef] [PubMed]
[23] Gagnepain, P., Hulbert, J., & Anderson, M. C. (2017). Parallel Regulation of Memory and Emotion Supports the Suppression of Intrusive Memories. The Journal of Neuroscience, 37, 6423-6441.[CrossRef] [PubMed]
[24] Guo, Y., Schmitz, T. W., Mur, M., Ferreira, C. S., & Anderson, M. C. (2018). A Supramodal Role of the Basal Ganglia in Memory and Motor Inhibition: Meta-Analytic Evidence. Neuropsychologia, 108, 117-134.[CrossRef] [PubMed]
[25] Hertel, P. T., & Calcaterra, G. (2005). Intentional Forgetting Benefits from Thought Substitution. Psychonomic Bulletin & Review, 12, 484-489.[CrossRef] [PubMed]
[26] Huber, D. E., Tomlinson, T. D., Jang, Y., & Hopper, W. J. (2015). The Search of Associative Memory with Recovery Interference (SAM-RI) Memory Model and Its Application to Retrieval Practice Paradigms. In J. G. W. Raaijmakers, R. Goldstone, M. Steyvers, A. Criss, & R. Nosofsky (Eds.), Cognitive Modeling in Perception and Memory: A Festschrift for Richard M. Shiffrin (pp. 81-98). Psychology Press.
[27] Hulbert, J. C., Henson, R. N., & Anderson, M. C. (2016). Inducing Amnesia through Systemic Suppression. Nature Communications, 7, Article No. 11003.[CrossRef] [PubMed]
[28] Lambert, A. J., Good, K. S., & Kirk, I. J. (2010). Testing the Repression Hypothesis: Effects of Emotional Valence on Memory Suppression in the Think—No Think Task. Consciousness and Cognition, 19, 281-293.[CrossRef] [PubMed]
[29] Levy, B. J., & Anderson, M. C. (2002). Inhibitory Processes and the Control of Memory Retrieval. Trends in Cognitive Sciences, 6, 299-305.[CrossRef] [PubMed]
[30] Levy, B. J., & Anderson, M. C. (2008). Individual Differences in the Suppression of Unwanted Memories: The Executive Deficit Hypothesis. Acta Psychologica, 127, 623-635.[CrossRef] [PubMed]
[31] Levy, B. J., & Anderson, M. C. (2012). Purging of Memories from Conscious Awareness Tracked in the Human Brain. The Journal of Neuroscience, 32, 16785-16794.[CrossRef] [PubMed]
[32] López‐Caneda, E., Crego, A., Campos, A. D., González‐Villar, A., & Sampaio, A. (2019). The Think/No‐Think Alcohol Task: A New Paradigm for Assessing Memory Suppression in Alcohol‐Related Contexts. Alcoholism: Clinical and Experimental Research, 43, 36-47.[CrossRef] [PubMed]
[33] Lu, F., Yang, W., & Qiu, J. (2023). Neural Bases of Motivated Forgetting of Autobiographical Memories. Cognitive Neuroscience, 14, 15-24.[CrossRef] [PubMed]
[34] Mamat, Z., & Anderson, M. C. (2023). Improving Mental Health by Training the Suppression of Unwanted Thoughts. Science Advances, 9, eadh5292.[CrossRef] [PubMed]
[35] Mary, A., Dayan, J., Leone, G., Postel, C., Fraisse, F., Malle, C. et al. (2020). Resilience after Trauma: The Role of Memory Suppression. Science, 367, eaay8477.[CrossRef] [PubMed]
[36] Murray, B. D., Anderson, M. C., & Kensinger, E. A. (2015). Older Adults Can Suppress Unwanted Memories When Given an Appropriate Strategy. Psychology and Aging, 30, 9-25.[CrossRef] [PubMed]
[37] Nardo, D., & Anderson, M. C. (2024). Everything You Ever Wanted to Know about the Think/no-Think Task, but Forgot to Ask. Behavior Research Methods, 56, 3831-3860.[CrossRef] [PubMed]
[38] Nishiyama, S., & Saito, S. (2022). Retrieval Stopping Can Reduce Distress from Aversive Memories. Cognition and Emotion, 36, 957-974.[CrossRef] [PubMed]
[39] Nørby, S. (2015). Why Forget? on the Adaptive Value of Memory Loss. Perspectives on Psychological Science, 10, 551-578.[CrossRef] [PubMed]
[40] Paz-Alonso, P. M., Bunge, S. A., Anderson, M. C., & Ghetti, S. (2013). Strength of Coupling within a Mnemonic Control Network Differentiates Those Who Can and Cannot Suppress Memory Retrieval. The Journal of Neuroscience, 33, 5017-5026.[CrossRef] [PubMed]
[41] Paz-Alonso, P. M., Ghetti, S., Matlen, B. J., Anderson, M. C., & Bunge, S. A. (2009). Memory Suppression Is an Active Process That Improves over Childhood. Frontiers in Human Neuroscience, 3, Artilcle 2009.[CrossRef] [PubMed]
[42] Satish, A., Hellerstedt, R., Anderson, M. C., & Bergström, Z. M. (2022). EEG Evidence That Morally Relevant Autobiographical Memories Can Be Suppressed. Cognitive, Affective, & Behavioral Neuroscience, 22, 1290-1310.[CrossRef] [PubMed]
[43] Schmitz, T. W., Correia, M. M., Ferreira, C. S., Prescot, A. P., & Anderson, M. C. (2017). Hippocampal GABA Enables Inhibitory Control over Unwanted Thoughts. Nature Communications, 8, Article No. 1311.[CrossRef] [PubMed]
[44] Singer, A., Darchi, S., Levy, D., & Sadeh, T. (2024). Intentional Forgetting Needs Intentional Remembering. Journal of Experimental Psychology: General, 153, 827-836.[CrossRef] [PubMed]
[45] Tanaka, K. Z., Pevzner, A., Hamidi, A. B., Nakazawa, Y., Graham, J., & Wiltgen, B. J. (2014). Cortical Representations Are Reinstated by the Hippocampus during Memory Retrieval. Neuron, 84, 347-354.[CrossRef] [PubMed]
[46] Tomlinson, T. D., Huber, D. E., Rieth, C. A., & Davelaar, E. J. (2009). An Interference Account of Cue-Independent Forgetting in the No-Think Paradigm. Proceedings of the National Academy of Sciences of the United States of America, 106, 15588-15593.[CrossRef] [PubMed]
[47] van Schie, K., Fawcett, J. M., & Anderson, M. C. (2023). On the Role of Inhibition in Suppression-Induced Forgetting. Scientific Reports, 13, Article No. 4242.[CrossRef] [PubMed]
[48] Vlasceanu, M., & Morais, M. J. (2019). A Possible Neural Mechanism of Intentional Forgetting. The Journal of Neuroscience, 39, 7642-7644.[CrossRef] [PubMed]
[49] Waldhauser, G. T., Dahl, M. J., Ruf-Leuschner, M., Müller-Bamouh, V., Schauer, M., Axmacher, N. et al. (2018). The Neural Dynamics of Deficient Memory Control in Heavily Traumatized Refugees. Scientific Reports, 8, Article No. 13132.[CrossRef] [PubMed]
[50] Yan, Y., Hulbert, J. C., Zhuang, K., Liu, W., Wei, D., Qiu, J. et al. (2023). Reduced Hippocampal-Cortical Connectivity during Memory Suppression Predicts the Ability to Forget Unwanted Memories. Cerebral Cortex, 33, 4189-4201.[CrossRef] [PubMed]
[51] Yang, C., & Naya, Y. (2020). Hippocampal Cells Integrate Past Memory and Present Perception for the Future. PLOS Biology, 18, e3000876.[CrossRef] [PubMed]
[52] Yu, X., Ao, H., Liang, R., Li, O., & Gao, X. (2024). Memory Suppression Devalues Food Reward and Can Predict Long-Term Changes in Emotional Eating. Food Quality and Preference, 115, Article ID: 105100.[CrossRef
[53] Zhang, R., Yang, X., Yang, R., Xu, Z., Sui, N., & Gao, X. (2020). Wanting to Eat Matters: Negative Affect and Emotional Eating Were Associated with Impaired Memory Suppression of Food Cues. Appetite, 150, Article ID: 104660.[CrossRef] [PubMed]