外周血感染指标与男性胆囊炎的相关性 研究

A Study on the Correlation between Peripheral Blood Infection Indicators and Cholecystitis in Males

摘要: 目的：探讨外周血感染及炎症指标在男性胆囊炎患者中的变化规律，分析其与病情严重程度的相关性，为临床早期诊断、病情评估及治疗决策提供参考依据。方法：回顾选择常德市第一中医医院2024年1月至2025年12月期间收治确诊的268例胆囊炎男性患者为研究对象，根据病情分为急性单纯性胆囊炎组92例、急性化脓性胆囊炎组68例、急性坏疽穿孔性胆囊炎组57例及慢性胆囊炎组51例。检测所有患者外周血白细胞计数(WBC)、中性粒细胞计数(NEUT)、中性粒细胞/淋巴细胞比值(NLR)、C-反应蛋白(CRP)、降钙素原(PCT)水平，比较各组指标差异，分析各指标与胆囊炎严重程度的相关性及诊断价值。结果：急性胆囊炎各组WBC、NEUT、NLR、CRP、PCT水平均显著高于慢性胆囊炎组，其中急性坏疽穿孔性胆囊炎组升高最为显著(P < 0.05)；各指标均与男性胆囊炎严重程度呈正相关，NLR、CRP、PCT联合检测对重症胆囊炎的诊断效能优于单一指标。结论：外周血感染指标可客观反映男性胆囊炎患者的感染与炎症状态，NLR、CRP、PCT联合检测能够有效提升重症胆囊炎的早期识别效率，对临床诊疗及预后评估具有重要应用价值。

Abstract: Objective: To explore the changes in peripheral blood infection and inflammation indicators in male patients with cholecystitis, analyze their correlation with the severity of the disease, and provide a reference basis for early clinical diagnosis, disease assessment, and treatment decisions. Methods: A retrospective selection was made of 268 male patients with cholecystitis diagnosed and treated at the First Hospital of Traditional Chinese Medicine of Changde from January 2024 to December 2025 as the research subjects. They were divided into four groups based on the severity of the disease: 92 cases of acute simple cholecystitis, 68 cases of acute suppurative cholecystitis, 57 cases of acute gangrenous perforated cholecystitis, and 51 cases of chronic cholecystitis. The levels of white blood cell count (WBC), neutrophil count (NEUT), neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP), and procalcitonin (PCT) in peripheral blood were detected for all patients. The differences in these indicators among the groups were compared, and the correlations between the indicators and the severity of cholecystitis as well as their diagnostic values were analyzed. Results: The levels of WBC, NEUT, NLR, CRP, and PCT in the acute cholecystitis groups were significantly higher than those in the chronic cholecystitis group, with the most significant increase observed in the acute gangrenous perforated cholecystitis group (P < 0.05). All indicators were positively correlated with the severity of cholecystitis in male patients, and the combined detection of NLR, CRP, and PCT had a better diagnostic efficiency for severe cholecystitis than any single indicator. Conclusion: Peripheral blood infection indicators can objectively reflect the infection and inflammation status of male cholecystitis patients. The combined detection of NLR, CRP, and PCT can effectively improve the early identification rate of severe cholecystitis and has significant application value in clinical diagnosis and prognosis assessment.