中药基于足细胞损伤治疗肾病综合征研究现状
Research Status of Traditional Chinese Medicine in Treating Nephrotic Syndrome Based on Podocyte Injury
摘要: 肾病综合征(NS)是一组以大量蛋白尿、低蛋白血症、高脂血症及水肿为特征的临床综合征，足细胞损伤是其发病的核心环节。中医药治疗肾病综合征历史悠久，疗效确切，且在多靶点干预足细胞损伤方面具有独特优势。本文综述了肾病综合征中足细胞损伤的相关信号通路，包括PI3K/Akt、NF-κB、mTOR/AMPK及TGF-β1/Smads通路，并总结了近年来中药通过调控上述通路保护足细胞、减轻蛋白尿、改善肾功能的实验研究进展。未来应进一步深化机制研究，开展高质量临床试验，推动中西医结合治疗方案的优化。
Abstract: Nephrotic syndrome (NS) is a group of clinical syndromes characterized by massive proteinuria, hypoalbuminemia, hyperlipidemia, and edema, with podocyte injury being a central pathogenic mechanism. Traditional Chinese medicine (TCM) has a long history in the treatment of nephrotic syndrome, demonstrating definite therapeutic efficacy and unique advantages in multi-target intervention for podocyte injury. This article reviews the relevant signaling pathways involved in podocyte injury in nephrotic syndrome, including the PI3K/Akt, NF-κB, mTOR/AMPK, and TGF-β1/Smads pathways. It also summarizes recent experimental research progress on how Chinese herbal medicine protects podocytes, reduces proteinuria, and improves renal function by regulating these pathways. Future efforts should focus on deepening mechanistic research and conducting high-quality clinical trials to promote the optimization of integrated traditional Chinese and Western medicine treatment strategies.
文章引用：房峻毅. 中药基于足细胞损伤治疗肾病综合征研究现状[J]. 中医学, 2026, 15(4): 214-220. https://doi.org/10.12677/tcm.2026.154200

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