巨噬细胞免疫调节在颞下颌关节骨关节炎中的研究进展
Advances in Macrophage-Mediated Immune Regulation in Temporomandibular Joint Osteoarthritis
DOI: 10.12677/jcpm.2026.52129, PDF,   
作者: 胡嘉琪, 罗 平, 陈 磊：重庆医科大学附属口腔医院，重庆；口腔疾病研究重庆市重点实验室，重庆；口腔生物医学工程重庆市高校市级重点实验室，重庆；重庆市卫生健康委口腔生物医学工程重点实验室，重庆；张富贵*：重庆医科大学附属口腔医院，重庆
关键词: 巨噬细胞；颞下颌关节骨关节炎；炎症；极化；靶向治疗；Macrophages； Temporomandibular Joint Osteoarthritis； Inflammation； Polarization； Targeted Therapy
摘要: 颞下颌关节骨关节炎(TMJOA)是一种常见的颞下颌关节疾病，其发病机制复杂，涉及炎症反应、软骨退变以及软骨下骨重塑等多个过程。巨噬细胞作为固有免疫的核心细胞，在TMJOA的发生与进展中扮演着关键角色。近年来，研究聚焦于巨噬细胞通过M1/M2极化表型动态调控局部炎症与修复平衡，其分泌的炎性因子直接参与软骨破坏，并与滑膜微环境相互作用，共同推动疾病的进一步发展。本文综述了巨噬细胞在TMJOA发生发展中的关键作用，包括极化调控及其与软骨破坏、滑膜炎症、骨重塑、神经血管网络互作机制。此外，还探讨了基于巨噬细胞靶向治疗的潜在策略和最新研究进展。
Abstract: Temporomandibular joint osteoarthritis (TMJOA) is a common disorder of the temporomandibular joint, with a complex pathogenesis involving inflammatory responses, cartilage degeneration, and subchondral bone remodeling. Macrophages, as the core cells of innate immunity, play a crucial role in the occurrence and progression of TMJOA. In recent years, research has focused on the dynamic regulation of local inflammation and repair balance by macrophages through M1/M2 polarization phenotypes. The inflammatory factors secreted by them directly participate in cartilage destruction and interact with the synovial microenvironment, jointly promoting the further development of the disease. This article reviews the key role of macrophages in the occurrence and development of TMJOA, including polarization regulation and its interaction mechanisms with cartilage destruction, synovial inflammation, bone remodeling, and neural vascular network. Additionally, it discusses potential strategies for targeted macrophage therapy and the latest research progress.
文章引用：胡嘉琪, 罗平, 陈磊, 张富贵. 巨噬细胞免疫调节在颞下颌关节骨关节炎中的研究进展[J]. 临床个性化医学, 2026, 5(2): 302-308. https://doi.org/10.12677/jcpm.2026.52129

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