肌源性因子鸢尾素在成骨作用中的研究进展
Research Progress on the Role of the Myokine Irisin in Osteogenesis
DOI: 10.12677/acm.2026.1641397, PDF,   
作者: 翟乃发：济宁医学院临床医学院(附属医院)，山东 济宁；张英迈, 冯 立*：济宁市第一人民医院创伤外科，山东 济宁
关键词: 肌源性因子；鸢尾素；骨质疏松症；骨生成；Myokine； Irisin； Osteoporosis； Osteogenesis
摘要: 骨质疏松症是我国老年人的常见疾病，尤其是绝经后的老年女性群体。近年来研究发现肌源性因子鸢尾素在调控骨组织代谢中具有重要作用，肌肉不仅是运动系统的组成部分，而且肌肉的内分泌作用与骨骼息息相关，肌肉可合成和分泌多种肌源性因子，对骨骼的生长、发育、修复产生重要影响。肌源性因子鸢尾素可调节骨髓间充质干细胞、成骨细胞、破骨细胞、软骨细胞和骨细胞的功能，促进骨骼合成代谢、抑制骨骼分解代谢，对骨再生具有双重调控作用。本文对肌源性因子鸢尾素在成骨方面的作用机制进行综述，为监测和治疗骨质疏松症提供新的作用靶点。
Abstract: Osteoporosis is a common systemic metabolic bone disease among the elderly population in China, particularly in postmenopausal women. Recent evidence indicates that the myokine irisin plays a pivotal role in regulating bone tissue metabolism. Skeletal muscle is not only a structural component of the locomotor system but also an endocrine organ closely associated with bone. It synthesizes and secretes various myokines that exert significant influences on bone growth, development, and repair. Irisin regulates the functions of bone marrow mesenchymal stem cells (BMSCs), osteoblasts, osteoclasts, chondrocytes, and osteocytes, thereby promoting bone anabolic metabolism and inhibiting bone catabolic metabolism. Thus, it exerts dual regulatory effects on bone regeneration. This review summarizes the mechanisms underlying the osteogenic effects of irisin and provides novel targets for monitoring and treating osteoporosis.
文章引用：翟乃发, 张英迈, 冯立. 肌源性因子鸢尾素在成骨作用中的研究进展[J]. 临床医学进展, 2026, 16(4): 1608-1614. https://doi.org/10.12677/acm.2026.1641397

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