FN3K在疾病中的作用机制及靶向潜力： 聚焦癌症治疗

The Mechanism of FN3K in Diseases and Its Targeting Potential: A Focus on Cancer Treatment

摘要: 果糖胺-3-激酶(Fructosamine-3-kinase, FN3K)是一种代谢酶，其核心生物学功能是通过特异性催化糖基化蛋白质分子上的果糖胺残基发生磷酸化反应，介导蛋白质去糖化过程的发生。近年来，随着相关研究的不断深入，研究证据表明，FN3K不仅在糖尿病等疾病的病理生理过程中发挥着不可或缺的调控作用，更在癌症的发生、发展进程中承担着关键角色，其中，其通过调控Nrf2氧化应激，在癌症中发挥了重要作用。本文系统综述了FN3K的核心生物学功能及其在糖尿病、肾缺血再灌注损伤、白内障、癌症等多种疾病中的研究进展，着重阐述了其如何参与癌症发生发展，讨论了其作为新型癌症治疗靶点的潜在应用前景。

Abstract: Fructosamine-3-kinase (FN3K) is a metabolic enzyme whose core biological function is to mediate protein deglycation by specifically catalyzing the phosphorylation of fructosamine residues on glycated proteins. In recent years, with the continuous advancement of relevant studies, accumulating evidence has demonstrated that FN3K not only plays an indispensable regulatory role in the pathophysiological processes of diseases such as diabetes mellitus, but also serves a key function in the occurrence and development of cancer. Notably, FN3K exerts an important effect in cancer by regulating Nrf2-mediated oxidative stress. This paper systematically reviews the core biological functions of FN3K and the research progress of FN3K in various diseases including diabetes mellitus, renal ischemia-reperfusion injury, cataract and cancer, focuses on its involvement in carcinogenesis and cancer progression, and discusses its potential application prospects as a novel therapeutic target for cancer.