相火理论视角下胃阴亏虚胃痛的药对配伍研究

Research on Herb Pair Compatibility for Stomach Yin Deficiency Stomachache Based on Minister Fire Theory

摘要: 研究旨在破解胃阴亏虚型胃痛临床治疗困境。基于相火理论解析其核心病机，阐明药对的配伍规律及现代药理机制。通过研究梳理“相火妄动–阴液亏虚–胃腑失和”的病机链条，明确肾阴不足、肝失疏泄、相火久燔三条致痛路径，系统溯源六组核心药对的配伍演变，并结合现代药理验证其作用机制。结果表明，相火妄动灼伤胃阴是胃阴亏虚胃痛的核心病机，六组药对遵循“寒温并用、标本同治”原则，可通过抗氧化、抗炎、调节胃肠功能，多途径改善胃痛症状和逆转胃黏膜损伤。研究结论丰富了胃阴亏虚型胃痛辨证论治体系，为临床精准用药提供了依据，也推动了相火理论的现代化转化。

Abstract: This study aims to address the clinical challenges in the treatment of stomachache due to stomach-yin deficiency. Based on the minister fire theory, it analyzes the core pathogenesis, elucidates the compatibility rules of herb pairs and their modern pharmacological mechanisms. The research clarifies the pathogenesis chain of “exuberant minister fire → yin-fluid depletion → dysfunction of the stomach”, and identifies three pain-inducing pathways: kidney-yin insufficiency, liver failing to govern coursing and discharge, and prolonged scorching by minister fire. It systematically traces the evolutionary compatibility of six core herb pairs and verifies their mechanisms of action combined with modern pharmacology. The results demonstrate that scorching of stomach yin by exuberant minister fire is the core pathogenesis of stomachache due to stomach-yin deficiency. The six herb pairs follow the principle of “combining cold and warm herbs, treating both manifestation and root cause”. They can alleviate stomachache and reverse gastric mucosal injury through multiple pathways, including anti-oxidation, anti-inflammation, and regulation of gastrointestinal function. The conclusions enrich the syndrome differentiation and treatment system for stomachache of stomach-yin deficiency type, provide a basis for precise clinical medication, and promote the modern transformation of the minister fire theory.