乳腺癌患者报告结局的研究进展
Advances in Patient-Reported Outcomes for Breast Cancer
DOI: 10.12677/jcpm.2026.52136, PDF,    科研立项经费支持
作者: 李睿琪*, 田 超#：西南医科大学附属医院乳腺外科，四川 泸州；褚 婕：电子科技大学医学院，四川 成都
关键词: 乳腺癌；患者报告结局；电子患者报告结局(ePRO)；生活质量；数字健康；Breast Cancer； Patient-Reported Outcomes； ePRO； Quality of Life； Digital Health
摘要: 乳腺癌是全球女性发病率最高的恶性肿瘤，尽管早期筛查与综合治疗不断进展，其疾病负担仍然突出。乳腺癌生存率的显著提升推动着疾病管理模式从单纯的肿瘤控制转向生活质量与整体健康的综合关注。患者报告结局作为直接捕捉患者症状、功能及治疗体验的主观测量工具，正在成为传统生物医学指标的重要补充。本文系统梳理了乳腺癌PROs在测量工具演进、数字技术赋能及临床整合应用中的最新进展。研究表明，EORTC QLQ-BR42、FACT-B及BREAST-Q等特异性量表正朝向阶段特异性与模块化方向发展；以ePRO平台和人工智能为代表的数字技术，推动着PRO从间断性数据采集向连续性智能监测的范式转变；在乳腺外科全周期管理、治疗毒性监测及晚期生存期管理中，PROs已展现出改善决策质量与预后的临床价值。然而，PRO的临床转化仍面临证据实施鸿沟、技术壁垒与监管缺位等多重挑战。未来研究需聚焦于动态干预阈值的建立、PRO作为替代终点的监管认可，以及数字疗法与PRO的闭环整合，以推动以患者为中心的价值医疗在乳腺癌领域的深度落地。
Abstract: Breast cancer is the most common malignant tumor among women worldwide. Despite advances in early screening and comprehensive treatment, the disease burden remains substantial. Improved survival has shifted the focus of breast cancer management from tumor control alone to comprehensive care for quality of life and overall health. Patient-reported outcomes (PROs), as subjective measures capturing patients’ symptoms, function, and treatment experience, have become an important complement to traditional biomedical indicators. This article systematically reviews recent advances in PRO measurement tools, digital technology applications, and clinical integration in breast cancer. Specific scales including the EORTC QLQ-BR42, FACT-B, and BREAST-Q are evolving toward stage-specific and modular designs. Digital technologies such as electronic PRO (ePRO) and artificial intelligence have enabled a paradigm shift from intermittent assessment to continuous intelligent monitoring. PROs have shown clinical value in improving decision-making and prognosis in breast surgery, treatment toxicity surveillance, and advanced care. However, clinical translation is hindered by implementation gaps, technical barriers, and insufficient regulation. Future research should focus on establishing dynamic intervention thresholds, regulatory acceptance of PROs as surrogate endpoints, and closed-loop integration with digital therapeutics to advance patient-centered value-based care in breast cancer.
文章引用：李睿琪, 褚婕, 田超. 乳腺癌患者报告结局的研究进展[J]. 临床个性化医学, 2026, 5(2): 365-376. https://doi.org/10.12677/jcpm.2026.52136

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