基于Web of Science的关于2型糖尿病与牙周 稳态相关性领域的文献计量分析

Bibliometric Analysis of the Correlation between Type 2 Diabetes Mellitus and Periodontal Homeostasis Based on Web of Science

摘要: 目的：应用文献计量分析学方法分析近30年2型糖尿病与牙周稳态相关性领域的研究现状、研究热点及未来趋势。方法：检索Web of Science核心数据库中自建库起至2024年12月31日关于2型糖尿病与牙周稳态相关性研究领域的研究类和综述类文献，利用Excel、VOSviewer和CiteSpace (6.3.R1)软件进行国家、研究机构、作者、关键词及相关引文可视化分析。结果：最终纳入900篇文献，涉及74个国家或地区，1258个机构和4522位作者。通过分析发现全球在2型糖尿病与牙周稳态相关性研究领域的发文量整体呈增长趋势，美国是目前发文量及研究总被引用次数最多的国家。关键词分析结果表明在研究的起始阶段(1999~2004)各国的科学家以2型糖尿病与牙周稳态相互影响的病理生理机制为重点探讨两者关系，而近五年的研究重点已转向如何为处理多病共存的治疗提出更好的建议。共被引文献聚类分析结果显示，该领域包含多个聚类模块，如#0“systematic review”(系统评价)，#1“adiponectin”(脂联素)，#2“hemoglobin-a”(血红蛋白)，#3“oral microbiome”(口腔微生物)，#4“interleukin-1”(白细胞介素-1)，#5“obesity”(肥胖)，#6“retinopathy”(视网膜病变)，#7“bidirectional relationship”(双向关系)，#8“glucose tolerance”(葡萄糖耐量)等研究方向。研究前沿主要聚焦于多病共存的综合管理策略等方面。结论：近30年2型糖尿病与牙周稳态相关性领域的研究主要聚焦于2型糖尿病与牙周炎相互影响的病理生理机制，当前研究热点逐步转向多病共存的综合管理策略，未来需进一步探索两者之间未阐明的分子机制，并逐渐面向临床，为多病共存的患者提出更佳的治疗建议。

Abstract: Objective: To analyze the current status, research hotspots, and future trends in the field of the correlation between type 2 diabetes mellitus (T2DM) and periodontal homeostasis over the past 30 years using bibliometric methods. Methods: Research articles and reviews related to T2DM and periodontal homeostasis were retrieved from the Web of Science Core Collection up to December 31, 2024. Excel, VOSviewer, and CiteSpace (6.3. R1) were employed to conduct visual analyses of countries, institutions, authors, keywords, and co-cited references. Results: A total of 900 articles were included, involving 74 countries or regions, 1258 institutions, and 4522 authors. The analysis revealed a global upward trend in publications on this topic. The United States contributed the highest number of publications and total citations. Keyword analysis indicated that early research (1999~2004) focused on elucidating the pathophysiological mechanisms underlying the bidirectional relationship between T2DM and periodontal homeostasis. In contrast, recent studies (past five years) have shifted toward proposing improved strategies for managing multimorbidity. Co-citation clustering identified multiple research themes, including #0 “systematic review,” #1 “adiponectin,” #2 “hemoglobin-A,” #3 “oral microbiome,” #4 “interleukin-1,” #5 “obesity,” #6 “retinopathy,” #7 “bidirectional relationship,” and #8 “glucose tolerance”. Current research frontiers emphasize comprehensive management strategies for coexisting chronic conditions. Conclusion: Over the past three decades, research on the correlation between T2DM and periodontal homeostasis has primarily focused on their pathophysiological interactions. Current hotspots are gradually transitioning toward integrated management strategies for multimorbidity. Future studies should further explore unelucidated molecular mechanisms and translate findings into clinical applications to optimize therapeutic recommendations for patients with coexisting chronic diseases.