原发性高血压患者血清可溶性生长刺激表达 基因2蛋白与早期心脏重构的相关性研究

Study on the Correlation between Serum Soluble ST2 and Early Cardiac Remodeling in Patients with Essential Hypertension

摘要: 目的：探讨原发性高血压患者血清可溶性生长刺激表达基因2蛋白(sST2)与早期心脏重构的相关性。方法：选取2023年9月至2024年7月于心血管内科就诊的原发性高血压患者153例，根据超声心动图将病例分为两组：左心房正常组、左心房增大组；收集其临床资料并用ELISA法检测患者血清sST2水平，比较两组血清sST2水平，Spearman法分析血清sST2与心脏重构指标的相关性(左心房前后径、舒张末期室间隔厚度、左心室舒张末期内径、左心室收缩末期内径)。结果：左心房正常组106例，左心房增大组47例，左心房增大组较左心房正常组sST2水平显著升高(15.71 ± 8.80 ng/ml vs 12.47 ± 6.34 ng/ml, P = 0.026)；sST2水平与左心房前后径(r = 0.199, P = 0.014)、室间隔厚度(r = 0.165, P = 0.042)呈正相关，sST2水平与左心室舒张末期内径、左心室收缩末期内径、左心室舒张末期容积、左心室收缩末期容积、射血分数无显著相关性(P > 0.05)。结论：原发性高血压患者血清sST2水平与左心房前后径及室间隔厚度存在微弱正相关，但未发现与其他左心室重构指标相关，提示sST2可能主要反映早期向心性重构而非左心室腔扩大。

Abstract: Objective: To investigate the association between serum soluble ST2 (sST2) levels and early cardiac remodeling in patients with essential hypertension. Methods: A total of 153 patients with essential hypertension admitted to the Department of Cardiology between September 2023 and July 2024 were enrolled. Based on echocardiographic findings, they were categorized into two groups: normal left atrium group and enlarged left atrium group. Clinical data were collected, and serum sST2 levels were measured using Enzyme-Linked Immunosorbent Assay (ELISA). The sST2 levels were compared between the two groups, and Spearman’s correlation analysis was employed to evaluate the relationship between sST2 levels and cardiac remodeling parameters, including left atrial anterior-posterior diameter, end-diastolic interventricular septal thickness, left ventricular end-diastolic diameter, and left ventricular end-systolic diameter. Results: A total of 153 patients with essential hypertension were included and categorized into two groups based on echocardiographic findings: the normal Left Atrium (LA) group (n = 106) and the enlarged LA group (n = 47). Serum soluble ST2 (sST2) level was significantly higher in the enlarged LA group than in the normal LA group (15.71 ± 8.80 ng/mL vs 12.47 ± 6.34 ng/mL, P = 0.026). Spearman correlation analysis revealed that sST2 level was positively correlated with left atrial anterior-posterior diameter (r = 0.199, P = 0.014) and interventricular septal thickness at end-diastole (r = 0.165, P = 0.042). In contrast, no significant correlations were observed between sST2 level and the following left ventricular parameters: end-diastolic diameter, end-systolic diameter, end-diastolic volume, end-systolic volume, or ejection fraction (all P > 0.05). Conclusion: Serum sST2 level is weakly positively correlated with left atrial diameter and interventricular septal thickness in patients with essential hypertension, but not with other left ventricular remodeling indices, suggesting that sST2 may primarily reflect early concentric remodeling rather than left ventricular cavity dilatation.