儿童激素耐药型肾病综合征(SRNS) 不良预后的危险因素
Risk Factors for Adverse Prognosis in Childhood Steroid-Resistant Nephrotic Syndrome (SRNS)
DOI: 10.12677/acm.2026.1641435, PDF,   
作者: 徐小明, 阳海平：重庆医科大学附属儿童医院肾脏内科，重庆
关键词: 激素耐药；肾病综合征；预后；危险因素；儿童；Steroid Resistance； Nephrotic Syndrome； Prognosis； Risk Factors； Children
摘要: 肾病综合征(Nephrotic Syndrome, NS)是儿童常见的肾小球疾病，以肾病分为蛋白尿、低白蛋白血症、高脂血症和水肿为主要临床表现。儿童肾病综合征包括多种类型，其中儿童激素耐药型肾病综合征(Steoid-Resistant Nephrotic Syndrome in children, SRNS)是一种少见但临床上具有挑战性的肾小球疾病。与激素敏感型肾病综合征相比，SRNS的预后相对较差，且治疗难度较大。因此，聚焦于儿童激素耐药性肾病综合征，本综述旨在通过分析现有报道的SRNS预后相关研究，探讨影响预后的因素及其相互作用，为临床医生提供诊疗经验，制定更为精准的治疗方案，提高患儿的生活质量和预后。
Abstract: Nephrotic Syndrome (NS) is a common glomerular disease in children, characterized by nephrotic-range proteinuria, hypoalbuminemia, hyperlipidemia, and edema as the main clinical manifestations. Pediatric nephrotic syndrome includes various types, among which Steroid-Resistant Nephrotic Syndrome (SRNS) in children is a rare but clinically challenging glomerular disease. Compared with steroid-sensitive nephrotic syndrome, SRNS has a relatively poor prognosis and greater treatment difficulty. Therefore, focusing on steroid-resistant nephrotic syndrome in children, this review aims to explore prognostic factors and their interactions by analyzing the existing studies on SRNS prognosis, so as to provide diagnostic and therapeutic experience for clinicians, formulate more precise treatment plans, and improve the quality of life and prognosis of children with SRNS.
文章引用：徐小明, 阳海平. 儿童激素耐药型肾病综合征(SRNS) 不良预后的危险因素 [J]. 临床医学进展, 2026, 16(4): 1935-1941. https://doi.org/10.12677/acm.2026.1641435

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