脂肪间充质干细胞及其衍生物改善皮肤衰老的研究进展
Research Progress on Anti-Skin Aging Effects of Adipose-Derived Mesenchymal Stem Cells and Their Derivatives
DOI: 10.12677/acm.2026.1641453, PDF,   
作者: 项佳妮, 楼培真, 吴慧玲*：浙江大学医学院，浙江 杭州；浙江大学医学院附属第一医院整形美容中心，浙江 杭州
关键词: 脂肪干细胞；皮肤衰老；细胞外囊泡；外泌体；氧化应激；胶原代谢；Adipose-Derived Stem Cells； Skin Aging； Extracellular Vesicles； Exosomes； Oxidative Stress； Collagen Metabolism
摘要: 脂肪间充质干细胞(ADSC)及其衍生物在皮肤抗衰老领域展现出广阔的应用前景。皮肤衰老涉及氧化应激、自噬–凋亡失衡、慢性炎症及胶原代谢紊乱等多重机制。ADSC通过旁分泌效应，其条件培养基、细胞外囊泡及外泌体等衍生物能够在分子层面清除活性氧、修复线粒体功能；在细胞层面调控自噬与凋亡平衡、抑制炎症反应；在组织层面促进胶原合成、抑制胶原降解，从而维持皮肤稳态。尽管ADSC衍生物在标准化生产、递送效率及临床证据方面仍面临挑战，但随着工程化修饰与递送技术的进步，其有望成为改善皮肤衰老的关键治疗策略。
Abstract: Adipose-derived stem cells (ADSC) and their derivatives demonstrate promising potential in the field of skin anti-aging. Skin aging involves multiple mechanisms including oxidative stress, dysregulation of autophagy-apoptosis balance, chronic inflammation, and collagen metabolic disorders. Through paracrine effects, ADSC-derived conditioned medium, extracellular vesicles, and exosomes exert therapeutic effects at multiple levels: eliminating reactive oxygen species and restoring mitochondrial function at the molecular level; regulating autophagy-apoptosis balance and inhibiting inflammatory responses at the cellular level; and promoting collagen synthesis while inhibiting collagen degradation at the tissue level, thereby maintaining skin homeostasis. Although challenges remain in standardized production, delivery efficiency, and clinical evidence for ADSC derivatives, advancements in engineering modification and delivery technologies position them as promising therapeutic strategies for ameliorating skin aging.
文章引用：项佳妮, 楼培真, 吴慧玲. 脂肪间充质干细胞及其衍生物改善皮肤衰老的研究进展[J]. 临床医学进展, 2026, 16(4): 2078-2090. https://doi.org/10.12677/acm.2026.1641453

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