肿瘤相关性肌少症影响因素的Meta分析
Risk Factors for Tumor-Associated Sarcopenia: A Meta-Analysis
DOI: 10.12677/acm.2026.1641457, PDF,   
作者: 李婷婷：黑龙江中医药大学研究生院，黑龙江 哈尔滨；聂 宏*：黑龙江中医药大学附属第一医院治未病中心，黑龙江 哈尔滨；杨 雪, 王露佳, 张 煜：滕州市中心人民医院，山东 枣庄
关键词: 肿瘤；肌少症；危险因素；Meta分析；Neoplasms； Sarcopenia； Risk Factors； Meta-Analysis
摘要: 目的：通过Meta分析了解肿瘤相关性肌少症的危险因素，为预防肿瘤患者发生肌少症提供依据。方法：计算机检索中国知网、万方、维普、CBM、PubMed、Web of Science、the Cochrane Library中关于癌症患者并发肌少症危险因素的文献，检索时限为建库至2023年4月。采用RevMan5.4及Stata14.0软件进行Meta分析。结果：最终纳入文献24篇，其中中文7篇，英文17篇，共10,902例研究对象。Meta分析影响因素结果显示，年龄(OR = 1.06, 95%CI: 1.04~1.08, P < 0.001)、性别(OR = 2.69, 95%CI: 1.44~5.03, P = 0.002)、BMI (OR = 0.78, 95%CI: 0.75~0.81, P < 0.001)、NRS评分(OR = 1.87, 95%CI: 1.47~2.39, P < 0.001)、肿瘤分期(OR = 1.81, 95%CI: 1.09~3.00, P = 0.02)、NLR (OR = 2.25, 95%CI: 1.48~3.42, P < 0.001)、糖尿病(OR = 2.11, 95%CI: 1.22~3.65, P = 0.008)、LMR (OR = 1.80, 95%CI: 1.43~2.26, P < 0.001)是肿瘤相关性肌少症的危险因素。结论：年龄、性别、BMI、NRS评分、肿瘤分期、NLR、糖尿病、LMR是肿瘤相关性肌少症的危险因素。医务人员可参考本研究结论，注重癌症患者肌少症的早期筛查与预防，早期实施干预措施，以维持肌肉力量和改善肌肉功能。
Abstract: Objective: Meta-analysis was performed to understand the risk factors of tumor-associated sarcopenia and provide evidence for the prevention of sarcopenia in tumor patients. Methods: The literatures on the risk factors of sarcopenia in cancer patients were retrieved from CNKI, Wanfang, VIP, CBM, PubMed, Web of Science and the Cochrane Library. The retrieval time was from inception to April 2023. Meta-analysis was performed using RevMan5.4 and Stata14.0 software. Results: 24 literatures were included, including 7 in Chinese and 17 in English, with a total of 10,902 subjects. The results of Meta-analysis of influencing factors showed that Age (OR = 1.06, 95%CI: 1.04~1.08, P < 0.001), gender (OR = 2.69, 95%CI: 1.44~5.03, P = 0.002), BMI (OR = 0.78, 95%CI: 0.75~0.81, P < 0.001), NRS (OR = 1.87, 95%CI: 1.47~2.39, P < 0.001), tumor staging (OR = 1.81, 95%CI: 1.09~3.00, P = 0.02), NLR (OR = 2.25, 95%CI: 1.48~3.42, P < 0.001), diabetes (OR = 2.11, 95%CI: 1.22~3.65, P = 0.008), LMR (OR = 1.80, 95%CI: 1.43~2.26, P < 0.001) were risk factors for tumor-associated sarcopenia. Conclusion: Age, sex, BMI, NRS score, tumor stage, NLR, diabetes and LMR are risk factors for tumor-associated sarcopenia. Medical staff can refer to the conclusion of this study, pay attention to the early screening and prevention of sarcopenia in cancer patients, and implement early intervention measures to maintain muscle strength and improve muscle function.
文章引用：李婷婷, 聂宏, 杨雪, 王露佳, 张煜. 肿瘤相关性肌少症影响因素的Meta分析[J]. 临床医学进展, 2026, 16(4): 2115-2124. https://doi.org/10.12677/acm.2026.1641457

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