聚己内酯在引导性骨组织再生中的应用、 进展及前景：一篇系统性综述

Polycaprolactone in Guided Bone Regeneration: Applications, Advances, and Future Perspectives—A Systematic Review

摘要: 引导性骨组织再生(Guided Bone Regeneration, GBR)是口腔种植、牙周治疗及颌骨缺损修复领域中修复骨缺损的主要方法。GBR膜作为该项技术的核心之一，其性能在很大程度上决定了骨再生的效果。聚己内酯(Polycaprolactone, PCL)是一种FDA批准的生物可降解聚合物，凭借其优异的机械性能、可控的降解速率和卓越的可加工性，已成为替代传统屏障膜的理想候选材料。然而，PCL本身的疏水性和生物惰性极大地限制了其在促进细胞黏附和诱导骨再生方面的应用，所以对于PCL进行功能化改性已成为骨组织工程领域的研究热点。本文旨在系统性地综述PCL基GBR膜的最新研究进展。首先本文回顾了制造PCL基膜的关键技术；接着详细阐述赋予PCL膜生物活性的三大功能化路径；最后总结当前PCL基GBR膜面临的挑战，并展望PCL在支架领域的未来发展方向，旨在为下一代高性能GBR膜的设计提供理论基础和创新思路。

Abstract: Guided Bone Regeneration (GBR) is a principal approach for the repair of bone defects in dental implantology, periodontal therapy, and maxillofacial defect reconstruction. As one of the core components of this technique, the performance of the GBR membrane largely determines the outcome of bone regeneration. Polycaprolactone (PCL) is an FDA-approved biodegradable polymer that has emerged as an attractive alternative to conventional barrier membranes due to its excellent mechanical properties, controllable degradation rate, and outstanding processability. However, the inherent hydrophobicity and bioinert nature of PCL markedly limit its ability to promote cell adhesion and induce bone regeneration, making functional modification of PCL a major research focus in the field of bone tissue engineering. This article aims to systematically review the latest research advances in PCL-based GBR membranes. First, key technologies for the fabrication of PCL-based membranes are summarized. Next, three major functionalization strategies for endowing PCL membranes with bioactivity are discussed in detail. Finally, the current challenges faced by PCL-based GBR membranes are outlined, and future perspectives for the development of PCL in scaffold-based applications are proposed, with the goal of providing a theoretical foundation and innovative insights for the design of next-generation high-performance GBR membranes.