微孔透皮导入与皮内注射平阳霉素联合二氧化碳点阵激光治疗增生性瘢痕自身前后临床观察

Clinical Observation before and after Microporous Transdermal Injection and Intradermal Injection of Pingyangmycin Combined with Carbon Dioxide Dot Matrix Laser in the Treatment of Hypertrophic Scar Itself

摘要: 探讨微孔透皮导入平阳霉素联合二氧化碳点阵激光与皮下注射平阳霉素联合二氧化碳点阵激光对增生性瘢痕疗效、皮肤镜及副作用的评价。方法：选取2023年5月~2023年12月于我院接受治疗的60例增生性瘢痕患者，依据抽签法，分为对照组(n = 30)与观察组(n = 30)。对照组予以C0₂点阵激光联合透皮导入平阳霉素，观察组平阳霉素皮损内注射后联合二氧化碳点阵激光治疗，比较两组临床疗效、增生性瘢痕血管分布、柔软性、厚度、色泽评分及不良反应发生率。结果：微孔透皮导入平阳霉素与皮下注射平阳霉素疗效更佳，皮损恢复一致，且副作用少，患者痛苦小，是患者可耐受的治疗方式。

Abstract: To evaluate the efficacy, dermoscopy and side effects of microporous transdermal injection of Pingyangmycin combined with carbon dioxide dot matrix laser and subcutaneous injection of Pingyangmycin combined with carbon dioxide dot matrix laser on hyperplastic scars. Methods: Sixty patients with hypertrophic scar treated in our hospital from May 2023 to December 2023 were selected and divided into control group (n = 30) and observation group (n = 30) according to lottery method. The control group was treated with CO₂ dot matrix laser combined with transdermal injection of Pingyangmycin, and the observation group was treated with carbon dioxide dot matrix laser after intracutaneous injection of Pingyangmycin. The clinical efficacy, vascular distribution, flexibility, thickness, color score and incidence of adverse reactions of the two groups were compared. Results: Microporous transdermal injection of Pingyangmycin has better curative effect than subcutaneous injection of Pingyangmycin, and the recovery of skin lesions is consistent, and the side effects are less, and the pain of patients is less.