多囊卵巢综合征中雄激素增高机制的研究进展
Research Progress on the Mechanism of Androgen Hyperplasia in Polycystic Ovary Syndrome
DOI: 10.12677/acm.2026.1641497, PDF,   
作者: 张馨艺：湖北医药学院湖北省妇幼保健院研究生培养基地，湖北 武汉；姚冬梅*：湖北省妇幼保健院盆底康复科，湖北 武汉
关键词: 多囊卵巢综合征；雄激素；内分泌代谢；发病机制；综述；Polycystic Ovary Syndrome； Androgen； Endocrine Metabolism； Pathogenesis； Review
摘要: 多囊卵巢综合征(Polycystic Ovary Syndrome, PCOS)是生殖期女性比较常见的一种内分泌代谢紊乱疾病，以高雄激素血症(Hyperandrogenism, HA)和胰岛素抵抗(Insulin Resistance, IR)为典型。PCOS涉及多种病理生理改变，其中雄激素过多作为重要病变环节对排卵障碍和IR均有重要影响，是诊断标准之一。卵巢、肾上腺和外周组织等均为雄激素代谢异常的一环，HA引发的月经异常、多毛痤疮、排卵障碍等症状，严重损害了患者的生殖健康与生活质量。然而，该病病因至今未明且发病机制复杂，可能与遗传、肠道菌群、炎症等有关。本文结合国内外研究最新进展，就PCOS患者中高雄激素血症的发生机制进行综述。
Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine metabolic disorder in reproductive-age women, characterized by hyperandrogenism (HA) and insulin resistance (IR). PCOS involves multiple pathophysiological changes, among which excessive androgen levels serve as a critical pathological mechanism influencing both ovulatory dysfunction and IR, constituting one of the diagnostic criteria. The ovaries, adrenal glands, and peripheral tissues are all implicated in the abnormal androgen metabolism. HA-induced symptoms such as menstrual irregularities, hirsutism, acne, and ovulatory disorders severely impair patients’ reproductive health and quality of life. However, the etiology of this condition remains unclear, and its pathogenesis is complex, potentially involving genetic factors, gut microbiota, and inflammation. This article reviews the mechanisms of hyperandrogenism in PCOS patients based on the latest domestic and international research findings.
文章引用：张馨艺, 姚冬梅. 多囊卵巢综合征中雄激素增高机制的研究进展[J]. 临床医学进展, 2026, 16(4): 2467-2476. https://doi.org/10.12677/acm.2026.1641497

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