多肽水凝胶的可设计性、刺激响应性与生物医学应用研究
Studies on the Designability, Stimulus Responsiveness and Biomedical Applications of Peptide Hydrogels
DOI: 10.12677/ms.2026.164077, PDF,    科研立项经费支持
作者: 徐凯利, 赵东欣*：河南工业大学化学化工学院，河南 郑州
关键词: 多肽水凝胶；可设计性；刺激响应性；生物医学材料；Peptide Hydrogel； Designability； Stimulus Responsiveness； Biomedical Materials
摘要: 多肽水凝胶是多肽分子间通过共价与非共价作用自组装而形成的具有三维网络结构的凝胶材料，其三维多孔网络结构可有效模拟细胞外基质，为细胞黏附、增殖与生长提供理想的仿生微环境。除了具有高含水量、低毒性、生物相容性与生物可降解性外，多肽水凝胶还具有高度可设计性，许多多肽水凝胶还具有pH、温度、酶、金属离子、氧化还原等多重刺激响应能力，因此多肽水凝胶在药物递送、抗菌材料、组织工程与细胞培养、智能传感、神经再生等方面有巨大的应用潜力。本文综述了多肽水凝胶的可设计性、刺激响应性及其在生物医学中的主要应用，分析了其实际应用中面临的关键挑战，并展望了多功能水凝胶的未来发展方向，希望能为多功能智能生物医用材料的设计与开发提供参考。
Abstract: Peptide hydrogels are gel materials with a three-dimensional network structure, self-assembled by peptide molecules through covalent and non-covalent interactions. Their three-dimensional porous network can effectively mimic the extracellular matrix, providing an ideal biomimetic microenvironment for cell adhesion, proliferation and growth. In addition to high water content, low toxicity, biocompatibility and biodegradability, peptide hydrogels exhibit high designability. Moreover, many peptide hydrogels possess multiple stimulus-responsive properties toward pH, temperature, enzymes, metal ions, redox and other stimuli. Therefore, peptide hydrogels show great application potential in drug delivery, antibacterial materials, tissue engineering and cell culture, intelligent sensing, nerve regeneration and other fields. This paper reviews the designability, stimulus responsiveness and main biomedical applications of peptide hydrogels, analyzes the key challenges in practical applications of peptide hydrogels, and looks forward to the future development direction of multifunctional hydrogels, hoping to provide a reference for the design and development of multifunctional intelligent biomedical materials.
文章引用：徐凯利, 赵东欣. 多肽水凝胶的可设计性、刺激响应性与生物医学应用研究[J]. 材料科学, 2026, 16(4): 100-109. https://doi.org/10.12677/ms.2026.164077

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