M2型TAMs与E-cadherin对NSCLC-STAS病理分型的预测价值
M2-Type TAMs and E-cadherin as Predictors for Pathological Subtypes of Spread through Air Spaces in Non-Small Cell Lung Cancer
DOI: 10.12677/acm.2026.1641530, PDF,   
作者: 尹思琪, 任胜楠, 王 静, 于 壮, 冯龄鑫*：青岛大学附属医院肿瘤科，山东 青岛；信芳杰：青岛大学附属医院病理科，山东 青岛
关键词: 非小细胞肺癌；气道播散；E-钙黏蛋白；M2型肿瘤相关巨噬细胞；Non-Small Cell Lung Cancer； Spread through Air Spaces； E-cadherin； M2 Tumor-Associated Macrophages
摘要: 背景与目的：探讨E-钙粘蛋白(E-cadherin)与M2型肿瘤相关巨噬细胞(TAM，以CD68、CD163为标志物)的表达，对伴气道播散(STAS)的非小细胞肺癌(NSCLC)患者其病理分型的预测价值。方法：本研究回顾性分析了60例行根治性切除术的NSCLC伴STAS患者。采用免疫组织化学法检测肿瘤组织中E-cadherin、CD68及CD163的表达，并分析其与STAS分型的相关性。综合运用卡方检验、多元Logistic回归进行统计学分析。结果：本研究根据STAS的生长模式将其分为单细胞型、微乳头型和实性巢型。统计学分析结果表明E-cadherin的低表达(P = 0.035)以及CD163的高表达(P = 0.042)，是STAS不同病理分型的独立预测因素。结论：E-cadherin与M2型TAM (CD163)是预测NSCLC术后STAS病理分型的重要分子标志物。早期识别相应标志物有望辅助临床早期预测具有高风险病理特征的个体，为实施个性化治疗、改善预后提供新策略。
Abstract: Background and Objective: To investigate the predictive value of E-cadherin and M2-polarized tumor-associated macrophages (TAMs), identified by the biomarkers CD68 and CD163, for the pathological subtypes of spread through air spaces (STAS) in patients with non-small cell lung cancer (NSCLC). Methods: A retrospective cohort study was conducted on 60 patients with NSCLC accompanied by STAS who underwent curative-intent radical resection. Immunohistochemical staining was performed on tumor specimens to evaluate the expression levels of E-cadherin, CD68, and CD163. The correlation between these molecular markers and the distinct STAS morphological patterns was subsequently analyzed. Statistical assessment was conducted using the chi-squared test and multivariate logistic regression analysis. Results: Based on the predominant growth pattern of tumor cells within air spaces, STAS was classified into three subtypes: single cell, micropapillary, and solid nest. Multivariate logistic regression analysis revealed that low expression of E-cadherin (P = 0.035) and high expression of CD163 (P = 0.042) were independent predictive factors associated with the different pathological subtypes of STAS. Conclusion: E-cadherin and M2-type TAMs (as defined by CD163 expression) are significant molecular markers for predicting the pathological subtypes of postoperative STAS in NSCLC. Early identification of these markers may facilitate the preoperative or postoperative recognition of individuals harboring high-risk pathological features, thereby informing personalized treatment strategies and potentially improving clinical outcomes.
文章引用：尹思琪, 任胜楠, 信芳杰, 王静, 于壮, 冯龄鑫. M2型TAMs与E-cadherin对NSCLC-STAS病理分型的预测价值[J]. 临床医学进展, 2026, 16(4): 2758-2769. https://doi.org/10.12677/acm.2026.1641530

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