基于血小板探究柳穿鱼黄素治疗脓毒血症 潜在价值
Exploring the Potential Value of Pectolinarigenin in the Treatment of Sepsis Based on Platelets
DOI: 10.12677/acm.2026.1641551, PDF,   
作者: 慎儒乐, 周小茜, 郁子萱, 吴桐桐：浙江中医药大学第二临床医学院，浙江 杭州；胡梦娇*：浙江中医药大学基础医学院，浙江 杭州
关键词: 脓毒血症；血小板；中性粒细胞；免疫血栓；柳穿鱼黄素；Sepsis； Platelet； Neutrophil； Immunothrombosis； Pectolinarigenin
摘要: 脓毒血症是由感染引起的全身性炎症反应，其病理过程涉及炎症和抗炎平衡失调，炎症细胞功能异常及内皮细胞的损伤。在内皮损伤和炎症信号的双重作用下，血小板被大量激活，与中性粒细胞、内皮细胞相互作用，形成免疫血栓，导致局部微血栓形成及血小板和凝血因子的大量消耗，继而引发弥散性血管内凝血(DIC)。抗血小板治疗或可成为脓毒血症的潜在干预策略。本文就以上方面进行综述，总结血小板在脓毒血症作用机制及作为治疗脓毒血症靶点的潜在价值，旨在为治疗脓毒血症的研究提供参考。
Abstract: Sepsis is a systemic inflammatory response caused by infection, involving imbalance of inflammatory and anti-inflammatory responses, dysfunction of inflammatory cells, and endothelial injury. Under the dual effects of endothelial injury and inflammatory signals, platelets are extensively activated and interact with neutrophils and endothelial cells to form immunothrombosis, leading to local microthrombus formation and massive consumption of platelets and coagulation factors, which subsequently results in disseminated intravascular coagulation (DIC). Antiplatelet therapy may serve as a potential intervention strategy for sepsis. This article reviews the above aspects, summarizes the mechanisms of platelets in sepsis and their potential value as therapeutic targets, aiming to provide references for research on the treatment of sepsis.
文章引用：慎儒乐, 周小茜, 郁子萱, 吴桐桐, 胡梦娇. 基于血小板探究柳穿鱼黄素治疗脓毒血症 潜在价值[J]. 临床医学进展, 2026, 16(4): 2938-2944. https://doi.org/10.12677/acm.2026.1641551

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