腹腔热灌注化疗的研究进展
Advances in Hyperthermic Intraperitoneal Chemotherapy
DOI: 10.12677/acm.2026.1641591, PDF,    科研立项经费支持
作者: 练 达*, 侯代鑫, 刘鲲鹏, 姜 昊:佳木斯大学临床医学院,黑龙江 佳木斯;谢鹏宇#:佳木斯大学基础医学院,黑龙江 佳木斯
关键词: 腹腔热灌注化疗腹膜癌细胞减灭术腹膜转移癌Hyperthermic Intraperitoneal Chemotherapy Peritoneal Carcinomatosis Cytoreductive Surgery Peritoneal Metastatic Cancer
摘要: 腹腔热灌注化疗(Hyperthermic Intraperitoneal Chemotherapy, HIPEC)是腹膜癌(Peritoneal Carcinomatosis, PC)综合治疗的重要手段,具有腹腔化疗、热疗与化疗协同增效、可物理清除腹腔游离癌细胞的特点,弥补了传统全身化疗的腹膜屏障缺陷,同时联合细胞减灭术可显著提升腹膜癌患者的生存率。文章总结了HIPEC的研究进展,重点分析了其发展历史、作用原理、临床适应证与禁忌证、并发症及在各类肿瘤中的应用价值等,为腹膜癌患者个体化诊疗方案的制定提供参考。
Abstract: Hyperthermic Intraperitoneal Chemotherapy (HIPEC) is an essential approach for the comprehensive treatment of Peritoneal Carcinomatosis (PC). It integrates the advantages of intraperitoneal chemotherapy, the synergistic effect of hyperthermia and chemotherapy, and the physical clearance of free abdominal cancer cells. It compensates for the peritoneal barrier defect of traditional systemic chemotherapy, and its combination with cytoreductive surgery can significantly improve the survival rate of PC patients. This paper summarizes the research progress of HIPEC, with a focus on an analysis of its developmental history, mechanism of action, clinical indications and contraindications, complications, and application value in various tumors, so as to provide a reference for formulating individualized diagnosis and treatment plans for patients with peritoneal carcinomatosis.
文章引用:练达, 侯代鑫, 刘鲲鹏, 姜昊, 谢鹏宇. 腹腔热灌注化疗的研究进展[J]. 临床医学进展, 2026, 16(4): 3295-3304. https://doi.org/10.12677/acm.2026.1641591

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